Serum leptin and total dietary energy intake: the INTERLIPID Study.
Serum leptin and total dietary energy intake: the INTERLIPID Study.
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DOI：
10.1007/s00394-012-0469-3
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发表时间：
2013-09
影响因子：
5
通讯作者：
Stamler J
中科院分区：
文献类型：
--
作者：
Nakamura Y;Ueshima H;Okuda N;Murakami Y;Miura K;Kita Y;Okamura T;Okayama A;Turin TC;Choudhry SR;Rodriguez B;David Curb J;Stamler J
有人假设瘦素诱导的食欲抑制在肥胖个体中受损，但几乎没有人类证据证明这一点。我们调查了血清瘦素和总能量摄入之间的关系，使用INTERLIPID/INTERMAP数据的日裔美国人在夏威夷和日本在日本。采用标准化方法检测了两个人群样本中40-59岁男性和女性的血清瘦素和营养素摄入量，一个是夏威夷的日裔美国人（88名男性，94名女性），另一个是日本中部的日本人（123名男性，111名女性）。根据BMI分类（<25 kg/m2、25-29.9 kg/m2和≥30 kg/m2）分层的多元线性回归分析，并对可能的混杂因素进行调整，以检查对数瘦素与总膳食能量摄入之间的关系。多因素回归分析显示，在BMI < 25 kg/m2和BMI在25 ~ 25 kg/m2的人群中，log-leptin与膳食总能量摄入量无显著相关性;在BMI ≥ 30 kg/m2的人群中，log-leptin与膳食总能量摄入量呈显著负相关（P = 0.029），与体重和体力活动无关。仅在BMI < 25 kg/m2的受试者中，体力活动评分与膳食总能量摄入量呈显著正相关（P < 0.001）。瘦素与肥胖者的膳食能量摄入呈显著负相关，但在超重和正常体重的人中则不相关。
It has been hypothesized that leptin-induced appetite suppression is impaired in obese individuals, but little human evidence is available documenting this. We investigated relations between serum leptin and total energy intake using INTERLIPID/INTERMAP data on Japanese-Americans in Hawaii and Japanese in Japan. Serum leptin and nutrient intakes were examined by standardized methods in men and women aged 40–59 years from two population samples, one Japanese-American in Hawaii (88 men, 94 women), the other Japanese in central Japan (123 men, 111 women). Multiple linear regression analyses stratified by BMI category (<25 kg/m2, 25–29.9 kg/m2, and ≥30 kg/m2) with adjustment for possible confounders were used to examine the relation between log-leptin and total dietary energy intake. In multivariate regression analyses, in those with BMI < 25 kg/m2 and in those with BMI between 25 and kg/m2, log-leptin was not significantly related to total dietary energy intake; in those with BMI ≥ 30 kg/m2, it was significantly inversely related to total dietary energy intake (P = 0.029), independent of body weight and physical activity. Physical activity score was significantly positively related to total dietary energy intake only in participants with BMI < 25 kg/m2 (P < 0.001). Leptin was significantly inversely associated with dietary energy intake in obese persons, but not in overweight and normal-weight persons.
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影响因子：
4.9
作者：
Chu, NF;Spiegelman, D;Rimm, EB
通讯作者：
Rimm, EB
影响因子：
7.1
作者：
Kissileff, Harry R.;Thornton, John C.;Rosenbaum, Michael
通讯作者：
Rosenbaum, Michael
DOI：
10.1002/j.1550-8528.1997.tb00284.x
发表时间：
1997-01-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Nicklas, BJ;Katzel, LI;Goldberg, AP
通讯作者：
Goldberg, AP
影响因子：
15.9
作者：
Schoeller, DA;Cella, LK;Caro, JF
通讯作者：
Caro, JF
影响因子：
5.8
作者：
Rosenbaum, M;Nicolson, M;Leibel, RL
通讯作者：
Leibel, RL