Association of maternal genital and reproductive infections with verbal memory and motor deficits in adult schizophrenia.
Association of maternal genital and reproductive infections with verbal memory and motor deficits in adult schizophrenia.
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DOI：
10.1016/j.psychres.2011.04.020
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发表时间：
2011-07-30
影响因子：
11.3
通讯作者：
McKeague, Ian W.
中科院分区：
文献类型：
--
作者：
Brown, Alan S.;Vinogradov, Sophia;Kremen, William S.;Poole, John H.;Bao, Yuanyuan;Kern, David;McKeague, Ian W.
在以前的研究中，母亲暴露于生殖器和生殖系统感染与精神分裂症有关。精神分裂症患者明显存在多种神经心理功能障碍，包括言语记忆、工作记忆、执行功能和精细运动协调。然而，这些缺陷的病因在很大程度上仍然未知。我们的目的是评估是否前瞻性记录的母亲暴露于生殖器/生殖感染与这些神经心理缺陷的后代与精神分裂症和其他精神分裂症谱系障碍。这些病例来自基于人群的出生队列;所有队列成员都属于预付健康计划。评估病例的言语记忆、工作记忆、执行功能和精细运动协调。与未暴露病例相比，暴露于母体生殖器/生殖感染的患者在言语记忆、精细运动协调和工作记忆方面表现更差。按种族分层揭示了母亲G/R感染与非裔美国母亲的病例后代的言语记忆和精细运动协调之间的关联，但不适用于白色母亲的病例后代。还观察到显著的感染-种族相互作用。虽然独立的复制是必要的，母亲G/R感染与非裔美国精神分裂症患者的言语记忆和运动功能缺陷。
Maternal exposure to genital and reproductive infections has been associated with schizophrenia in previous studies. Impairments in several neuropsychological functions, including verbal memory, working memory, executive function, and fine-motor coordination occur prominently in patients with schizophrenia. The etiologies of these deficits, however, remain largely unknown. We aimed to assess whether prospectively documented maternal exposure to genital/reproductive infections was related to these neuropsychological deficits in offspring with schizophrenia and other schizophrenia spectrum disorders. The cases were derived from a population-based birth cohort; all cohort members belonged to a prepaid health plan. Cases were assessed for verbal memory, working memory, executive function, and fine-motor coordination. Compared to unexposed cases, patients exposed to maternal genital/reproductive infection performed more poorly on verbal memory, fine-motor coordination, and working memory. Stratification by race revealed associations between maternal G/R infection and verbal memory and fine-motor coordination for case offspring of African-American mothers, but not for case offspring of White mothers. Significant infection-by-race interactions were also observed. Although independent replications are warranted, maternal G/R infections were associated with verbal memory and motor function deficits in African-American patients with schizophrenia.
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