c-Fos expression in the paternal mouse brain induced by communicative interaction with maternal mates.
c-Fos expression in the paternal mouse brain induced by communicative interaction with maternal mates.
复制标题
DOI：
10.1186/s13041-014-0066-x
复制
发表时间：
2014-09-11
期刊：
影响因子：
3.6
通讯作者：
Higashida H
中科院分区：
文献类型：
--
作者：
Zhong J;Liang M;Akther S;Higashida C;Tsuji T;Higashida H
父亲适当的父母照顾极大地促进了人类家庭生活的健康。与影响母亲行为的因素和神经回路相比，动物研究对影响父亲行为的因素和神经回路的了解要少得多。我们最近报道，当ICR小鼠父系与幼崽分开并与它们的配偶关在笼子里(共居)时，它们表现出母系般的取回行为，因为它们通过超声波和信息素信号从水坝接收交流互动。我们通过量化c-Fos免疫反应细胞作为男性父母行为神经通路中的神经元激活标记物，研究了参与调节这种活动的大脑结构。在有提取行为的雄性(取回者)中，视前内侧区(MPOA)c-Fos的表达显著高于没有这种行为的雄性(无取回者)。在超声波发声或来自配偶的信息素刺激下，寻回犬的mPOA区的表达也同样增加。腹侧被盖区(VTA)、伏隔核(NAcc)和腹侧钯(Vp)的表达未见增加。在我们确定寻回犬和非寻回犬家族的第二天，寻回犬与其配偶在新笼子中隔离时，其mPOA、VTA、NAcc和VP区神经元亚群中c-Fos的表达显著增加。这种差异在新笼子中单独隔离的寻回犬种犬中没有观察到。非寻回猎犬的公马在被评估的四个大脑区域没有表现出表达的变化。MPOA神经元似乎是通过与配偶坝的直接交流相互作用而激活的，包括超声波发声和信息素。MPOA-VTA-NAcc-VP神经回路似乎参与了父亲的提取行为。
Appropriate parental care by fathers greatly facilitates health in human family life. Much less is known from animal studies regarding the factors and neural circuitry that affect paternal behavior compared with those affecting maternal behavior. We recently reported that ICR mouse sires displayed maternal-like retrieval behavior when they were separated from pups and caged with their mates (co-housing) because the sires receive communicative interactions via ultrasonic and pheromone signals from the dams. We investigated the brain structures involved in regulating this activity by quantifying c-Fos-immunoreactive cells as neuronal activation markers in the neural pathway of male parental behavior. c-Fos expression in the medial preoptic area (mPOA) was significantly higher in sires that exhibited retrieval behavior (retrievers) than those with no such behavior (non-retrievers). Identical increased expression was found in the mPOA region in the retrievers stimulated by ultrasonic vocalizations or pheromones from their mates. Such increases in expression were not observed in the ventral tegmental area (VTA), nucleus accumbens (NAcc) or ventral palladium (VP). On the following day that we identified the families of the retrievers or non-retrievers, c-Fos expression in neuronal subsets in the mPOA, VTA, NAcc and VP was much higher in the retriever sires when they isolated together with their mates in new cages. This difference was not observed in the singly isolated retriever sires in new cages. The non-retriever sires did not display expression changes in the four brain regions that were assessed. The mPOA neurons appeared to be activated by direct communicative interactions with mate dams, including ultrasonic vocalizations and pheromones. The mPOA-VTA-NAcc-VP neural circuit appears to be involved in paternal retrieval behavior.
登录
查看更多内容
影响因子：
3.5
作者：
Rosenblatt, JS;Hazelwood, S;Poole, J
通讯作者：
Poole, J
影响因子：
3.5
作者：
de Jong, Trynke R.;Chauke, Miyetani;Saltzman, Wendy
通讯作者：
Saltzman, Wendy
影响因子：
2.9
作者：
Lee, Anna W.;Brown, Richard E.
通讯作者：
Brown, Richard E.
影响因子：
3.2
作者：
Bosch, O. J.;Pfoertsch, J.;Neumann, I. D.
通讯作者：
Neumann, I. D.
影响因子：
56.9
作者：
MORGAN, JI;COHEN, DR;CURRAN, T
通讯作者：
CURRAN, T