Linear and inverted U-shaped dose-response functions describe estrogen effects on hippocampal activity in young women.
Linear and inverted U-shaped dose-response functions describe estrogen effects on hippocampal activity in young women.
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DOI：
10.1038/s41467-018-03679-x
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发表时间：
2018-03-23
影响因子：
16.6
通讯作者：
Sommer T
中科院分区：
文献类型：
--
作者：
Bayer J;Gläscher J;Finsterbusch J;Schulte LH;Sommer T
在动物体内，17-β-雌二醇(E_2)以剂量依赖、单调递增的方式增强海马可塑性，但这种关系也可以表现出倒U形功能。为了研究E2‘S在人类海马区的剂量反应功能，我们采用安慰剂对照设计，从药物上将125名自然周期妇女(处于低激素月经期)的E2水平提高到生理水平(相当于月经周期的峰值)和生理水平(相当于怀孕早期的水平)。在首次摄入雌激素24小时后，检测中性图片和负性图片编码过程中的脑活动，并在编码后24 小时测试再认记忆。在此，我们报道了雌二醇与海马区的活动呈单调递增关系，也呈倒U形关系，这取决于海马区。表现出U型关系的海马区活动影响超生理水平的E2，这表明虽然生理范围内的E2刺激海马区的活动，但超生理学范围显示出相反的效果。虽然已知雌激素会改变动物的海马体活动，但尚不清楚这种影响是否会延伸到人类。在这里，作者在年轻女性中改变了雌激素的剂量，并表明对海马体活动的影响可以用线性和倒U型剂量-反应函数来描述。
In animals, 17-beta-estradiol (E2) enhances hippocampal plasticity in a dose-dependent, monotonically increasing manner, but this relationship can also exhibit an inverted U-shaped function. To investigate E2’s dose-response function in the human hippocampus, we pharmacologically increased E2 levels in 125 naturally cycling women (who were in their low-hormone menstruation phase) to physiological (equivalent to menstrual cycle peak) and supraphysiological (equivalent to levels during early pregnancy) concentrations in a placebo-controlled design. Twenty-four hours after first E2 intake, we measured brain activity during encoding of neutral and negative pictures and then tested recognition memory 24 h after encoding. Here we report that E2 exhibits both a monotonically increasing relationship with hippocampal activity as well as an inverted U-shaped relationship, depending on the hippocampal region. Hippocampal activity exhibiting a U-shaped relationship inflects at supraphysiological E2 levels, suggesting that while E2 within physiological ranges stimulates hippocampal activity, supraphysiological ranges show opposite effects. While estrogen is known to change hippocampal activity in animals, it is not known if this effect extends to humans. Here, authors vary the doses of estrogen in young women and show that the effects on hippocampal activity can be described by linear and inverted-U shaped dose-response functions.
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影响因子：
5.7
作者：
Andreano, Joseph M.;Cahill, Larry
通讯作者：
Cahill, Larry
DOI：
10.1177/1073858413519865
发表时间：
2014-10
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Bean LA;Ianov L;Foster TC
通讯作者：
Foster TC
影响因子：
3.2
作者：
Barha, C. K.;Lieblich, S. E.;Galea, L. A. M.
通讯作者：
Galea, L. A. M.
影响因子：
3.3
作者：
Aydin, M.;Yilmaz, B.;Tuzcu, M.
通讯作者：
Tuzcu, M.
影响因子：
5.3
作者：
Goldstein, JM;Jerram, M;Makris, N
通讯作者：
Makris, N