Menstrual cycle modulation of medial temporal activity evoked by negative emotion.
Menstrual cycle modulation of medial temporal activity evoked by negative emotion.
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DOI：
10.1016/j.neuroimage.2010.07.011
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发表时间：
2010-12
期刊：
影响因子：
5.7
通讯作者：
Cahill, Larry
中科院分区：
文献类型：
--
作者：
Andreano, Joseph M.;Cahill, Larry
先前的研究表明，女性的下丘脑 - 垂体 - 肾上腺（HPA）轴活动和杏仁核反应性存在与月经周期相关的差异，即在月经周期的高雌激素阶段，对负面情绪图片的反应会降低。其他研究表明，外源性孕酮有相反的作用，在某些剂量下会增加杏仁核的活动。然而，到目前为止，还没有研究评估在黄体期（此时孕酮和雌激素水平都升高）大脑的唤醒回路对负面图片的反应。为了解决这个问题，对17名自然月经周期的女性分别在月经周期的早卵泡期和中黄体期进行扫描，并通过功能性磁共振成像（fMRI）评估对国际情感图片系统（IAPS）图片的反应。结果显示，与早卵泡期的扫描相比，中黄体期扫描时海马体和杏仁核的活动显著增加。这些发现表明，在黄体期孕酮介导的作用占主导，并且进一步表明雌激素和孕酮在调节大脑的唤醒回路中可能起相反的作用。
Previous studies have indicated phase-related differences in HPA activity and amygdala responsiveness in women, such that the response to negative emotional images is reduced during high-estrogen phases of the menstrual cycle. Other research has indicated an opposite effect of exogenous progesterone, increasing amygdala activity at some doses. However, no study to date has assessed the response of the brain’s arousal circuitry to negative images during the luteal phase, when both progesterone and estrogen levels are elevated. To address this question, 17 naturally cycling women were each scanned during the early follicular and mid-luteal phases of the cycle, and response to IAPS images was assessed by fMRI. The results indicated significantly increased activity in hippocampus and amygdala during mid-luteal scans when compared to scans in the early follicular phase. These findings suggest that progesterone-mediated effects dominate during the luteal-phase, and further suggest that estrogen and progesterone may play opposing roles in modulating the brain’s arousal circuitry.
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DOI：
10.1523/jneurosci.3021-09.2010
发表时间：
2010-01-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Goldstein JM;Jerram M;Abbs B;Whitfield-Gabrieli S;Makris N
通讯作者：
Makris N
影响因子：
3.5
作者：
Craig, Michael C.;Fletcher, Paul C.;Murphy, Declan G. M.
通讯作者：
Murphy, Declan G. M.
影响因子：
5.7
作者：
Maldjian, JA;Laurienti, PJ;Burdette, JH
通讯作者：
Burdette, JH
影响因子：
5.3
作者：
Goldstein, JM;Jerram, M;Makris, N
通讯作者：
Makris, N
影响因子：
3.7
作者：
Bouma, Esther M. C.;Riese, Harriette;Oldehinkel, Albertine J.
通讯作者：
Oldehinkel, Albertine J.