Spectral-Domain OCT Measurements in Alzheimer's Disease: A Systematic Review and Meta-analysis.
Spectral-Domain OCT Measurements in Alzheimer's Disease: A Systematic Review and Meta-analysis.
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DOI：
10.1016/j.ophtha.2018.08.009
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发表时间：
2019-04
期刊：
影响因子：
13.7
通讯作者：
Cheung CY
中科院分区：
文献类型：
--
作者：
Chan VTT;Sun Z;Tang S;Chen LJ;Wong A;Tham CC;Wong TY;Chen C;Ikram MK;Whitson HE;Lad EM;Mok VCT;Cheung CY
光学相干断层扫描(OCT)是一种非侵入性工具，可以测量眼睛中特定的视网膜层。视网膜光谱域-OCT(SD-OCT)测量与阿尔茨海默病(AD)和轻度认知障碍(MCI)的关系尚不清楚。因此，我们进行了系统的回顾和荟萃分析来检验AD和MCI的SD-OCT测量结果。目前诊断早期阿尔茨海默病的方法昂贵且具有侵入性。SD-OCT的视网膜测量无创、技术简单、价格低廉，是潜在的AD生物标志物。我们对PubMed和EMbase进行了文献检索，以确定2017年12月31日之前发表的研究，这些研究评估了AD和MCI与SD-OCT的相关性：神经节细胞-内丛状层(GC-IPL)、神经节细胞复合体(GCC)、黄斑体积和脉络膜厚度，以及视网膜神经纤维层(RNFL)和黄斑厚度。我们使用随机效应模型来检验这些关系。我们还进行了Meta回归，并评估了异质性、发表偏倚和研究质量。我们确定了30项符合条件的研究，涉及1257名AD受试者，305名MCI受试者和1460名对照；所有研究都是横断面研究。在黄斑结构方面，AD患者的GCPL厚度(标准化平均差，−0.46；95%可信区间，−0.80至−0.11；I2=71%)、GCC厚度(SMD，−0.84；95%CI，−1.10至−0.57；I2=0%)、黄斑体积(SMD，−0.58；95%CI，−1.03至−0.14)、黄斑体积(SMD，−0.58；95%CI，−1.03至−0.14；I2=80%)和黄斑厚度(SMD0.52至−0.74；均P<；0.001)与对照组比较。AD组视盘周围视网膜神经纤维层厚度(−为0.67；95%CI，−为0.95~−0.38；I2=89%)和脉络膜厚度(SMD值为−0.88~-1.03，P均<0.001)也变薄。我们的结果证实了SD-OCT的视网膜测量与AD之间的关联，强调了SD-OCT测量作为AD的生物标志物的潜在用途。
Optical coherence tomography (OCT) is a non-invasive tool to measure specific retinal layers in the eye. The relationship of retinal spectral domain-OCT (SD-OCT) measurements with Alzheimer’s Disease (AD) and mild cognitive impairment (MCI) remains unclear. Hence, we conducted a systematic review and meta-analysis to examine the SD-OCT measurements in AD and MCI. Current methods of diagnosing early AD are expensive and invasive. Retinal measurements of SD-OCT, which are non-invasive, technically simple and inexpensive, are potential biomarkers of AD. We conducted a literature search in PubMed and EMBASE to identify studies published before 31 December 2017 which assessed the associations between AD, MCI and measurements of SD-OCT: ganglion cell-inner plexiform layer (GC-IPL), ganglion cell complex (GCC), macular volume and choroidal thickness, in addition to retinal nerve fibre layer (RNFL) and macular thickness. We used a random-effect model to examine these relationships. We also conducted meta-regression, and assessed heterogeneity, publication bias and study quality. We identified 30 eligible studies, involving 1257 AD subjects, 305 MCI subjects and 1460 controls; all of which were cross-sectional studies. In terms of the macular structure, AD subjects had significant differences in GC-IPL thickness (standardized mean difference [SMD], −0.46; 95% confidence interval [CI], −0.80 to −0.11; I2 = 71%), GCC thickness (SMD, −0.84; 95% CI, −1.10 to −0.57; I2 = 0%), macular volume (SMD, −0.58; 95% CI, −1.03 to −0.14; I2 = 80%) and macular thickness of all inner and outer sectors (SMD ranged −0.52 to −0.74; all p<0.001) when compared to controls. Peripapillary RNFL thickness (SMD, −0.67; 95% CI, −0.95 to −0.38; I2 = 89%) and choroidal thickness (SMD ranged −0.88 to - 1.03; all p<0.001) were also thinner in AD. Our results confirmed the associations between retinal measurements of SD-OCT, and AD, highlighting the potential utility of SD-OCT measurements as biomarkers of AD.
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影响因子：
--
作者：
Baker, Michelle L.;Wang, Jie Jin;Rogers, Sophie;Klein, Ronald;Kuller, Lewis H.;Larsen, Emily K.;Wong, Tien Yin
通讯作者：
Wong, Tien Yin
影响因子：
--
作者：
Chen, TC;Cense, B;de Boer, JF
通讯作者：
de Boer, JF
DOI：
10.1016/j.jalz.2011.03.008
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Albert MS;DeKosky ST;Dickson D;Dubois B;Feldman HH;Fox NC;Gamst A;Holtzman DM;Jagust WJ;Petersen RC;Snyder PJ;Carrillo MC;Thies B;Phelps CH
通讯作者：
Phelps CH
影响因子：
4.2
作者：
Blanks, JC;Torigoe, Y;Blanks, RHI
通讯作者：
Blanks, RHI
影响因子：
2.4
作者：
Bayer, AU;Ferrari, F;Erb, C
通讯作者：
Erb, C