A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor.
A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor.
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DOI：
10.1016/j.jpsychires.2014.10.003
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发表时间：
2015-01
影响因子：
4.8
通讯作者：
Otto, Michael W.
中科院分区：
文献类型：
--
作者：
Szuhany, Kristin L.;Bugatti, Matteo;Otto, Michael W.
一致的证据表明运动可以改善认知和情绪，初步证据表明脑源性神经营养因子（BDNF）可能介导这些作用。当前荟萃分析的目的是评估多种运动范式中运动与人类 BDNF 水平升高之间的关联强度。我们对 29 项研究（N = 1,111 名受试者）进行了荟萃分析，研究了三种运动范式中运动对 BDNF 水平的影响：(1) 单次运动，(2) 常规运动计划后的一次运动，以及 (3) 常规运动计划后的静息 BDNF 水平。还检查了这种效应的调节因素。结果表明，单次运动后 BDNF 增加的效果中等（Hedges’ g = 0.46，p < 0.001）。此外，定期运动增强了运动对 BDNF 水平的影响（Hedges’g = 0.58，p = 0.02）。最后，结果表明定期运动对静息 BDNF 水平影响很小（Hedges’g = 0.28，p = 0.005）。在跨范式分析结果时，性别显着调节了运动对 BDNF 水平的影响，因此对更多女性的研究表明，运动导致的 BDNF 变化较少。效应大小分析支持运动作为增强人类 BDNF 活性的策略的作用，但表明这些效应的程度在女性中可能低于男性。
Consistent evidence indicates that exercise improves cognition and mood, with preliminary evidence suggesting that brain-derived neurotrophic factor (BDNF) may mediate these effects. The aim of the current meta-analysis was to provide an estimate of the strength of the association between exercise and increased BDNF levels in humans across multiple exercise paradigms. We conducted a meta-analysis of 29 studies (N = 1,111 participants) examining the effect of exercise on BDNF levels in three exercise paradigms: (1) a single session of exercise, (2) a session of exercise following a program of regular exercise, and (3) resting BDNF levels following a program of regular exercise. Moderators of this effect were also examined. Results demonstrated a moderate effect size for increases in BDNF following a single session of exercise (Hedges’ g = 0.46, p < 0.001). Further, regular exercise intensified the effect of a session of exercise on BDNF levels (Hedges’ g = 0.58, p = 0.02). Finally, results indicated a small effect of regular exercise on resting BDNF levels (Hedges’ g = 0.28, p = 0.005). When analyzing results across paradigms, sex significantly moderated the effect of exercise on BDNF levels, such that studies with more women showed less BDNF change resulting from exercise. Effect size analysis supports the role of exercise as a strategy for enhancing BDNF activity in humans, but indicates that the magnitude of these effects may be lower in females relative to males.
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影响因子：
3.5
作者：
Erickson, Kirk I.;Prakash, Ruchika S.;Voss, Michelle W.;Chaddock, Laura;Hu, Liang;Morris, Katherine S.;White, Siobhan M.;Wojcicki, Thomas R.;McAuley, Edward;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
5
作者：
BLAIR, SN;HASKELL, WL;WOOD, PD
通讯作者：
WOOD, PD
DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Erickson, Kirk I.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
3.2
作者：
Corripio, Raquel;Gonzalez-Clemente, Jose-Miguel;Caixas, Assumpta
通讯作者：
Caixas, Assumpta
DOI：
10.1177/1073858410397054
发表时间：
2012-02
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Erickson KI;Miller DL;Roecklein KA
通讯作者：
Roecklein KA