Transmission history of SARS-CoV-2 in humans and white-tailed deer.
Transmission history of SARS-CoV-2 in humans and white-tailed deer.
复制标题
人类和白尾鹿的SARS-COV-2传播历史。
DOI：
10.1038/s41598-022-16071-z
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发表时间：
2022-07-15
影响因子：
4.6
通讯作者：
Conlan, Andrew J. K.
中科院分区：
文献类型：
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作者：
Willgert, Katriina;Didelot, Xavier;Surendran-Nair, Meera;Kuchipudi, Suresh, V;Ruden, Rachel M.;Yon, Michele;Nissly, Ruth H.;Vandegrift, Kurt J.;Nelli, Rahul K.;Li, Lingling;Jayarao, Bhushan M.;Levine, Nicole;Olsen, Randall J.;Davis, James J.;Musser, James M.;Hudson, Peter J.;Kapur, Vivek;Conlan, Andrew J. K.
在易感人群中出现一种新的病原体可能会导致感染的快速传播。据报道，在多个地点，白尾鹿(Odocoileus Virginianus)中SARS-CoV-2感染的高流行率，可能是由于几次人传鹿溢出事件以及随后的鹿传鹿传播造成的。了解SARS-CoV-2在人类和潜在宿主之间传播的风险和方向，对于有效控制疾病和确定干预措施的优先顺序至关重要。利用基因组数据，我们重建了SARS-CoV-2在人和鹿之间的传播史，估计了病例发现率，并试图推断物种之间的相对传播率。我们没有发现鹿直接或间接传播给人类的证据。然而，由于估计的病例发现率仅为4.2%，不能排除溢出到人类的可能性。SARS-CoV-2病毒在鹿群中的广泛传播和大量未抽样病例突显了在人与动物之间进行积极监测的必要性。
The emergence of a novel pathogen in a susceptible population can cause rapid spread of infection. High prevalence of SARS-CoV-2 infection in white-tailed deer (Odocoileus virginianus) has been reported in multiple locations, likely resulting from several human-to-deer spillover events followed by deer-to-deer transmission. Knowledge of the risk and direction of SARS-CoV-2 transmission between humans and potential reservoir hosts is essential for effective disease control and prioritisation of interventions. Using genomic data, we reconstruct the transmission history of SARS-CoV-2 in humans and deer, estimate the case finding rate and attempt to infer relative rates of transmission between species. We found no evidence of direct or indirect transmission from deer to human. However, with an estimated case finding rate of only 4.2%, spillback to humans cannot be ruled out. The extensive transmission of SARS-CoV-2 within deer populations and the large number of unsampled cases highlights the need for active surveillance at the human–animal interface.
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SARS-COV-2在人类和貂皮之间的貂皮农场上传播，然后回到人类。
DOI：
10.1126/science.abe5901
发表时间：
2021-01-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Oude Munnink BB;Sikkema RS;Nieuwenhuijse DF;Molenaar RJ;Munger E;Molenkamp R;van der Spek A;Tolsma P;Rietveld A;Brouwer M;Bouwmeester-Vincken N;Harders F;Hakze-van der Honing R;Wegdam-Blans MCA;Bouwstra RJ;GeurtsvanKessel C;van der Eijk AA;Velkers FC;Smit LAM;Stegeman A;van der Poel WHM;Koopmans MPG
通讯作者：
Koopmans MPG
影响因子：
4.3
作者：
Hobbs EC;Reid TJ
通讯作者：
Reid TJ
影响因子：
56.3
作者：
Al-Tawfiq, Jaffar A.;Zumla, Alimuddin;Memish, Ziad A.
通讯作者：
Memish, Ziad A.
影响因子：
2.5
作者：
Ballash, Gregory A.;Jenkins, Mark C.;Dennis, Patricia M.
通讯作者：
Dennis, Patricia M.
影响因子：
6.7
作者：
Martins M;Boggiatto PM;Buckley A;Cassmann ED;Falkenberg S;Caserta LC;Fernandes MHV;Kanipe C;Lager K;Palmer MV;Diel DG
通讯作者：
Diel DG