Phylogeographic diversity of pathogenic and non-pathogenic hantaviruses in slovenia.
Phylogeographic diversity of pathogenic and non-pathogenic hantaviruses in slovenia.
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DOI：
10.3390/v5123071
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发表时间：
2013-12-10
期刊：
影响因子：
--
通讯作者：
Županc TA
中科院分区：
文献类型：
--
作者：
Korva M;Knap N;Rus KR;Fajs L;Grubelnik G;Bremec M;Knapič T;Trilar T;Županc TA
从自然地理的角度来看，斯洛文尼亚是一个非常多样化的国家，在相对较小的地区内有许多不同的生境，此外还有重大的地质和气候差异。因此，几种小型哺乳动物被证实携带汉坦病毒也就不足为奇了。flavicollis（Dobrava virus）、多布拉瓦病毒A. agrarius（Dobrava virus-Kurkino），M. glareolus（Puumala病毒）、S. areanus（Seewis virus），M. agrestis，M. arvalis和M.（Tula病毒）。其中三种病毒，即Dobrava、Dobrava-Kurkino和Puumala病毒，会引起人类疾病，症状的严重程度有很大差异。由于肾综合征出血热（HFRS）病例流行病学的变化，对生态多样性流行区传播的致病性和非致病性汉坦病毒的系统发育多样性和分子流行病学进行了详细研究。这项研究是从一个国家的宿主和患者中获得的汉坦病毒L、M和S序列的最大集合之一。确定了每个汉坦病毒种的几个遗传谱系，与致病性病毒相比，非致病性病毒的多样性更高。对于致病性汉坦病毒，一个显着的人类和啮齿动物衍生的序列的地理聚类得到证实。一些地理和生态因素被认为影响和限制了地方病流行区的形成。
Slovenia is a very diverse country from a natural geography point of view, with many different habitats within a relatively small area, in addition to major geological and climatic differences. It is therefore not surprising that several small mammal species have been confirmed to harbour hantaviruses: A. flavicollis (Dobrava virus), A. agrarius (Dobrava virus–Kurkino), M. glareolus (Puumala virus), S. areanus (Seewis virus), M. agrestis, M. arvalis and M. subterraneus (Tula virus). Three of the viruses, namely the Dobrava, Dobrava–Kurkino and Puumala viruses, cause disease in humans, with significant differences in the severity of symptoms. Due to changes in haemorrhagic fever with renal syndrome cases (HFRS) epidemiology, a detailed study on phylogenetic diversity and molecular epidemiology of pathogenic and non-pathogenic hantaviruses circulating in ecologically diverse endemic regions was performed. The study presents one of the largest collections of hantavirus L, M and S sequences obtained from hosts and patients within a single country. Several genetic lineages were determined for each hantavirus species, with higher diversity among non-pathogenic compared to pathogenic viruses. For pathogenic hantaviruses, a significant geographic clustering of human- and rodent-derived sequences was confirmed. Several geographic and ecological factors were recognized as influencing and limiting the formation of endemic areas.
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