High-Density Porous Graphene Arrays Enable Detection and Analysis of Propagating Cortical Waves and Spirals.
High-Density Porous Graphene Arrays Enable Detection and Analysis of Propagating Cortical Waves and Spirals.
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DOI：
10.1038/s41598-018-35613-y
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发表时间：
2018-11-20
影响因子：
4.6
通讯作者：
Kuzum D
中科院分区：
文献类型：
--
作者：
Liu X;Lu Y;Kuzum D
皮质传播波最近引起了神经科学界的极大关注。这些行波被认为可以协调不同的大脑区域，并在辅助神经可塑性和学习方面发挥作用。然而，在大面积上以非常精细的空间尺度记录它们以研究它们对神经动力学或网络连接变化的影响是非常具有挑战性的。在这项工作中，我们采用高密度的多孔石墨微电极阵列制造的柔性基板上的激光热解研究皮层传播波过程中的功能网络连接。低阻抗多孔石墨烯阵列用于记录体内θ振荡和药物诱导癫痫发作期间的皮层电位。神经记录的时空分析表明，θ振荡和癫痫样活动的同步性和由此产生的传播波模式方面具有鲜明的特点。为了研究波传播过程中的网络连通性，我们进行了网络分析。结果表明，传播波与神经回路中的功能连接性变化一致，表明底层网络状态由皮层电位传播模式反映。
Cortical propagating waves have recently attracted significant attention by the neuroscience community. These travelling waves have been suggested to coordinate different brain areas and play roles in assisting neural plasticity and learning. However, it is extremely challenging to record them with very fine spatial scales over large areas to investigate their effect on neural dynamics or network connectivity changes. In this work, we employ high-density porous graphene microelectrode arrays fabricated using laser pyrolysis on flexible substrates to study the functional network connectivity during cortical propagating waves. The low-impedance porous graphene arrays are used to record cortical potentials during theta oscillations and drug-induced seizures in vivo. Spatiotemporal analysis on the neural recordings reveal that theta oscillations and epileptiform activities have distinct characteristics in terms of both synchronization and resulting propagating wave patterns. To investigate the network connectivity during the propagating waves, we perform network analysis. The results show that the propagating waves are consistent with the functional connectivity changes in the neural circuits, suggesting that the underlying network states are reflected by the cortical potential propagation patterns.
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影响因子：
16.6
作者：
Muller, Lyle;Reynaud, Alexandre;Chavane, Frederic;Destexhe, Alain
通讯作者：
Destexhe, Alain
影响因子：
16.2
作者：
Makino H;Ren C;Liu H;Kim AN;Kondapaneni N;Liu X;Kuzum D;Komiyama T
通讯作者：
Komiyama T
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
3
作者：
MILLIGAN, GW;COOPER, MC
通讯作者：
COOPER, MC
影响因子：
5.3
作者：
Andrade, Katia C.;Spoormaker, Victor I.;Czisch, Michael
通讯作者：
Czisch, Michael