The association of carotid artery atherosclerosis with the estimated excretion levels of urinary sodium and potassium and their ratio in Chinese adults.
The association of carotid artery atherosclerosis with the estimated excretion levels of urinary sodium and potassium and their ratio in Chinese adults.
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DOI：
10.1186/s12937-021-00710-8
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发表时间：
2021-06-06
影响因子：
5.4
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Peng S;Wang J;Xiao Y;Yin L;Peng Y;Yang L;Yang P;Wang Y;Cao X;Li X;Li Y
动脉硬化是一个独立的心血管危险因素。然而，钠/钾摄入量与血管僵硬度之间的关联并不一致。因此，进行了一项大型的基于社区的横断面研究，试图得出更明确的结论。在每位招募的参与者进行体检时，通过现场尿样检测尿钠、钾和肌酐水平。使用川崎公式（用作摄入量的替代值）确定24小时估计尿钠排泄量（eUNaE）和估计尿钾排泄量（eUKE）水平。使用超声波测量颈动脉内膜中层厚度（IMT）和斑块。在 13,523 名 18-80 岁的受试者中，分析了颈动脉斑块和 IMT 与 eUNaE、eUKE 及其比率之间的关系。总体而言，30.2% 的参与者被诊断出患有颈动脉斑块。有颈动脉斑块的个体的估计钠与钾排泄比（Na/K比）显着高于无斑块的参与者（2.14±0.73 vs. 2.09±0.61，P<0.01）。调整年龄、性别和其他生活方式协变量后，发现颈动脉斑块与Na/K比值之间存在显着正相关（OR = 1.06，P < 0.05）。在没有斑块的参与者中，Na/K 比值与分叉颈动脉 IMT 增加之间观察到类似的正相关（β = 0.008，P < 0.01），特别是在女性中（Pinteraction < 0.01）。在这项研究中，钠摄入量是根据测量的尿排泄量来估计的，尿钠的估计排泄水平高和/或尿钾的估计排泄水平低可能与中国人颈动脉粥样硬化的增加有关。在线版本包含可在 10.1186/s12937-021-00710-8 获取的补充材料。
Arterial stiffness is an independent cardiovascular risk factor. However, the association between sodium/potassium intake and vascular stiffness was inconsistent. Therefore, a large community-based cross-sectional study was performed to try and achieve more definitive conclusion. Urinary sodium, potassium, and creatinine levels were tested in spot urine samples during physical examinations of each recruited participant. The 24-h estimated urinary sodium excretion (eUNaE) and estimated urinary potassium excretion (eUKE) levels were determined using the Kawasaki formula (used as a surrogate for intake). Carotid intima-media thickness (IMT) and plaques were measured using ultrasound. In 13,523 subjects aged 18–80 years, the relationships between carotid plaques and IMT with eUNaE, eUKE and their ratios were analyzed. Overall, 30.2% of participants were diagnosed with carotid artery plaques. The ratio of estimated sodium vs. potassium excretion (Na/K ratio) of the individuals with carotid artery plaques was significantly higher than that of participants without plaque (2.14 ± 0.73 vs. 2.09 ± 0.61, P < 0.01). After adjusting for age, gender, and other lifestyle covariates, a significant positive relation was found between carotid plaque and Na/K ratios (OR = 1.06, P < 0.05). In participants without plaque, a similar positive association was observed between Na/K ratios and increased bifurcation carotid IMT (β = 0.008, P < 0.01), especially in the females (Pinteraction < 0.01). In this study, in which sodium intake was estimated on the basis of measured urinary excretion, high estimated excretion levels of urinary sodium and/or low estimated excretion levels of urinary potassium might be associated with an increased presence of carotid atherosclerosis in Chinese individuals. The online version contains supplementary material available at 10.1186/s12937-021-00710-8.
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作者：
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以家庭为基础的随机试验，检测含钾和钙的盐替代品对高血压青少年血压的影响
影响因子：
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