Spatial heterogeneity, host movement and mosquito-borne disease transmission.
Spatial heterogeneity, host movement and mosquito-borne disease transmission.
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DOI：
10.1371/journal.pone.0127552
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Smith DL
中科院分区：
文献类型：
--
作者：
Acevedo MA;Prosper O;Lopiano K;Ruktanonchai N;Caughlin TT;Martcheva M;Osenberg CW;Smith DL
蚊媒疾病是一个全球卫生优先事项，对热带和亚热带国家的低收入人口造成不成比例的影响。这些病原体生活在蚊子和宿主体内，在空间异质性环境中相互作用，宿主在不同传播强度的区域之间移动。虽然有越来越多的兴趣在蚊子传播的疾病动力学的空间过程的影响，我们的理解来自模型，假设空间均匀的传输。接触率的空间变化可以影响传播和流行病的风险，但空间异质性和宿主移动之间的相互作用仍然相对未被探索。在这里，我们探索，分析和通过数值模拟，人类流动性如何连接空间异质性蚊子种群，从而影响疾病的持续性（由基本繁殖数R 0决定），患病率和它们之间的关系。我们发现，当当地的传播率是高度异质性，R 0下降渐近人类流动性的增加，但感染率在低到中等的运动速度的峰值和下降渐近后，这个峰值。运动可以减少暴露于蚊子叮咬的异质性。因此，如果叮咬强度高，但不均匀，感染率增加与流动性，尽管减少R 0。这种流行率的增加随着流动性的进一步增加而减少，因为个人没有在高传播补丁中花费足够的时间，因此减少了新感染的数量和总体流行率。这些结果提供了一个更好的基础，了解空间传播异质性和人类流动性之间的相互作用，以及它们对患病率和R0的综合影响。
Mosquito-borne diseases are a global health priority disproportionately affecting low-income populations in tropical and sub-tropical countries. These pathogens live in mosquitoes and hosts that interact in spatially heterogeneous environments where hosts move between regions of varying transmission intensity. Although there is increasing interest in the implications of spatial processes for mosquito-borne disease dynamics, most of our understanding derives from models that assume spatially homogeneous transmission. Spatial variation in contact rates can influence transmission and the risk of epidemics, yet the interaction between spatial heterogeneity and movement of hosts remains relatively unexplored. Here we explore, analytically and through numerical simulations, how human mobility connects spatially heterogeneous mosquito populations, thereby influencing disease persistence (determined by the basic reproduction number R 0), prevalence and their relationship. We show that, when local transmission rates are highly heterogeneous, R 0 declines asymptotically as human mobility increases, but infection prevalence peaks at low to intermediate rates of movement and decreases asymptotically after this peak. Movement can reduce heterogeneity in exposure to mosquito biting. As a result, if biting intensity is high but uneven, infection prevalence increases with mobility despite reductions in R 0. This increase in prevalence decreases with further increase in mobility because individuals do not spend enough time in high transmission patches, hence decreasing the number of new infections and overall prevalence. These results provide a better basis for understanding the interplay between spatial transmission heterogeneity and human mobility, and their combined influence on prevalence and R 0.
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影响因子：
1.3
作者：
COLLINS, WE;WARREN, M;KEARSE, TS
通讯作者：
KEARSE, TS
DOI：
10.4269/ajtmh.2003.68.366
发表时间：
2003-03-01
影响因子：
3.3
作者：
Collins, WE;Jeffery, GM
通讯作者：
Jeffery, GM
影响因子：
15.8
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通讯作者：
Tanner M
影响因子：
2.3
作者：
Dietz, K
通讯作者：
Dietz, K
影响因子：
3.8
作者：
Barbu, Corentin;Dumonteil, Eric;Gourbiere, Sebastien
通讯作者：
Gourbiere, Sebastien