Comparison of 3.0 T proton magnetic resonance spectroscopy short and long echo-time measures of intramyocellular lipids in obese and normal-weight women.
Comparison of 3.0 T proton magnetic resonance spectroscopy short and long echo-time measures of intramyocellular lipids in obese and normal-weight women.
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DOI：
10.1002/jmri.22226
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发表时间：
2010-08
影响因子：
4.4
通讯作者：
Torriani, Martin
中科院分区：
文献类型：
--
作者：
Bredella, Miriam A.;Ghomi, Reza Hosseini;Thomas, Bijoy J.;Miller, Karen K.;Torriani, Martin
比较短和长回波时间质子磁共振波谱（1H-MRS）测量的肌内脂质（IMCL）与肥胖和正常体重女性的身体成分和胰岛素抵抗指数的相关性。我们使用3.0 T的单体素1H-MRS PRESS，短（30 msec）和长（144 msec）回波时间，对52名绝经前妇女（37名肥胖和15名正常体重）的胫骨前肌（TA）和比目鱼肌（SOL）肌肉的IMCL进行定量。进行统计分析，以确定IMCL与身体成分的相关性，如计算机断层扫描（CT）和胰岛素抵抗指数，并比较短和长回波时间数据的相关系数。信噪比（SNR），线宽，和变异系数（CV）的短和长回波时间谱计算。TA和SOL的短回波和长回波IMCL与体重指数（BMI）和腹部脂肪库显著相关（r = 0.32至0.70，P =<0.05），肝脏密度（r =-0.39至-0.50，P <0.05）和葡萄糖曲线下面积作为胰岛素抵抗的指标（r = 0.47至0.49，P <0.05）。短回波时间谱与长回波时间谱的相关系数无显著性差异（P> 0.5）。与长回波时间采集相比，两块肌肉中的短回波时间IMCL显示出显著更高的SNR（P <0.0001）和更低的CV。线宽测量在组间没有显著差异。在3.0 T下使用短和长回波时间1H-MRS进行IMCL定量可用于检测肥胖和正常体重受试者肌肉脂质含量的差异。此外，IMCL与该人群的身体成分和胰岛素抵抗标志物相关，短回波时间和长回波时间之间的相关性无显著差异。在3.0 T条件下，TA和SOL肌肉的短回波时间IMCL定量优于长回波时间，因为SNR和再现性更好。
To compare correlations of intramyocellular lipids (IMCL) measured by short and long echo-time proton magnetic resonance spectroscopy (1H-MRS) with indices of body composition and insulin resistance in obese and normal-weight women. We quantified IMCL of tibialis anterior (TA) and soleus (SOL) muscles in 52 premenopausal women (37 obese and 15 normal weight) using single-voxel 1H-MRS PRESS at 3.0 T with short (30 msec) and long (144 msec) echo times. Statistical analyses were performed to determine correlations of IMCL with body composition as determined by computed tomography (CT) and insulin resistance indices and to compare correlation coefficients from short and long echo-time data. Signal-to-noise ratio (SNR), linewidth, and coefficients of variation (CV) of short and long echo-time spectra were calculated. Short and long echo-time IMCL from TA and SOL significantly correlated with body mass index (BMI) and abdominal fat depots (r = 0.32 to 0.70, P = <0.05), liver density (r = −0.39 to −0.50, P < 0.05), and glucose area under the curve as a measure of insulin resistance (r = 0.47 to 0.49, P < 0.05). There was no significant difference between correlation coefficients of short and long echo-time spectra (P > 0.5). Short echo-time IMCL in both muscles showed significantly higher SNR (P < 0.0001) and lower CVs when compared to long echo-time acquisitions. Linewidth measures were not significantly different between groups. IMCL quantification using short and long echo-time 1H-MRS at 3.0 T is useful to detect differences in muscle lipid content in obese and normal-weight subjects. In addition, IMCL correlates with body composition and markers of insulin resistance in this population with no significant difference in correlations between short and long echo-times. Short echo-time IMCL quantification of TA and SOL muscles at 3.0 T was superior to long echo-time due to better SNR and better reproducibility.
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影响因子：
8.2
作者：
Krssak, M;Petersen, KF;Roden, M
通讯作者：
Roden, M
影响因子：
7.1
作者：
BORKAN, GA;GERZOF, SG;SILBERT, JE
通讯作者：
SILBERT, JE
影响因子：
19.7
作者：
Torriani, M;Thomas, BJ;Palmer, WE
通讯作者：
Palmer, WE
影响因子：
2.5
作者：
Jagannathan, NR;Wadhwa, S
通讯作者：
Wadhwa, S
DOI：
10.1007/s10334-003-0029-1
发表时间：
2004-03-01
影响因子：
2.3
作者：
Krssak, M;Mlynárik, V;Roden, M
通讯作者：
Roden, M