Delphinidin 3-rutinoside-rich blackcurrant extract ameliorates glucose tolerance by increasing the release of glucagon-like peptide-1 secretion.
Delphinidin 3-rutinoside-rich blackcurrant extract ameliorates glucose tolerance by increasing the release of glucagon-like peptide-1 secretion.
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DOI：
10.1002/fsn3.478
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发表时间：
2017-07
影响因子：
3.9
通讯作者：
Tsuda T
中科院分区：
文献类型：
--
作者：
Tani T;Nishikawa S;Kato M;Tsuda T
胰高血糖素样肽-1（GLP-1）是一种肠促胰岛素，由肠内分泌L-细胞分泌。内源性GLP-1的饮食因子刺激是增加GLP-1作用的一种有前景的策略。最近的研究表明，富含花青素的浆果可以提高胰岛素敏感性，降低患2型糖尿病的风险。我们先前的研究发现，花色素苷飞燕草素3-芸香糖苷（D3 R）显著增加GLUTag细胞（肠内分泌L细胞系）中GLP-1的分泌。黑醋栗是含有高水平花青素的浆果，特别是D3 R。预先给予黑醋栗提取物（BCE）5 mg/kg体重（1 mg D3 R/kg）通过刺激GLP-1的分泌并随后诱导胰岛素分泌，显着改善大鼠腹腔内注射葡萄糖后的葡萄糖耐量。BCE给药后至少45 - 60分钟，D3 R在胃肠道中没有显著分解，表明BCE诱导的GLP-1分泌主要由D3 R介导，而不是其降解产物。这些发现证明了富含D3 R的BCE作为GLP-1促分泌素的新生物学功能。BCE诱导的内源性GLP-1分泌增加可能有助于减少糖尿病药物的剂量并预防糖尿病。
Glucagon‐like peptide‐1 (GLP‐1) is an incretin that is secreted from enteroendocrine L‐cells. Dietary factor‐stimulation of endogenous GLP‐1 is a promising strategy for increasing the action of GLP‐1. Recent studies have shown that berries rich in anthocyanins improve insulin sensitivity and reduce the risk of type 2 diabetes. Our previous study found that the anthocyanin delphinidin 3‐rutinoside (D3R) significantly increases GLP‐1 secretion in GLUTag cells (enteroendocrine L cell line). Blackcurrants are berries that contain high levels of anthocyanins, particularly D3R. Pre‐administered blackcurrant extract (BCE) 5 mg/kg body weight (1 mg D3R/kg) significantly ameliorated glucose tolerance after intraperitoneal glucose injection in rats by stimulating the secretion of GLP‐1 and subsequently inducing insulin secretion. D3R did not break down significantly in the gastrointestinal tract for at least 45−60 min after BCE was administered, suggesting that BCE‐induced GLP‐1 secretion is mainly mediated by D3R and not its degradation products. These findings demonstrate the novel biological function of D3R‐rich BCE as a GLP‐1 secretagogue. An increase in endogenous GLP‐1 secretion induced by BCE may help to reduce the dosages of diabetic medicines and prevent diabetes.
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花色苷Delphinidin 3-鲁丁苷刺激通过Ca2+/钙调蛋白依赖性激酶II途径刺激鼠谷物细胞系中胰高血糖素样肽-1分泌。
影响因子：
3.7
作者：
Kato M;Tani T;Terahara N;Tsuda T
通讯作者：
Tsuda T
影响因子：
3.5
作者：
Keppler, K;Humpf, HU
通讯作者：
Humpf, HU
影响因子：
4.2
作者：
Takikawa, Masahiro;Inoue, Seiya;Tsuda, Takanori
通讯作者：
Tsuda, Takanori
影响因子：
5.2
作者：
Kern, Melanie;Fridrich, Diana;Marko, Doris
通讯作者：
Marko, Doris
影响因子：
6.1
作者：
Forester, Sarah C.;Waterhouse, Andrew L.
通讯作者：
Waterhouse, Andrew L.