Cingulo-hippocampal effective connectivity positively correlates with drug-cue attentional bias in opioid use disorder.
Cingulo-hippocampal effective connectivity positively correlates with drug-cue attentional bias in opioid use disorder.
复制标题
DOI：
10.1016/j.pscychresns.2019.08.005
复制
发表时间：
2019-12-30
期刊：
影响因子：
--
通讯作者：
Moeller FG
中科院分区：
文献类型：
--
作者：
Ma L;Steinberg JL;Bjork JM;Taylor BA;Arias AJ;Terplan M;Anastasio NC;Zuniga EA;Lennon M;Cunningham KA;Moeller FG
Individuals with opioid use disorder (OUD) often relapse when exposed to opioid-related cues. Previous functional magnetic resonance imaging (fMRI) studies have identified neuronal corticolimbic changes related to drug cue reactivity in OUD. However, the corresponding manner in which brain regions interact is still unclear. Effective (directional) connectivity was analyzed using dynamic causal modeling of fMRI data acquired from 27 OUD participants (13 with OUD and 14 with OUD and cocaine use disorder [OUD+CUD]), while performing an opioid-word Stroop task. Participants were shown opioid and neutral words presented in different colors and were instructed to indicate word color but ignore word meaning. The effects of opioid words relative to neutral words on effective connectivity and on behavioral reaction time were defined as modulatory change and attentional bias, respectively. For all the 27 participants, left anterior cingulate cortex (ACC) to right hippocampus effective connectivity exhibited the largest modulatory change, which was positively correlated with attentional bias. The findings for the ACC to hippocampus EC were consistent across OUD and CUD found in a previous study.
登录
查看更多内容
影响因子：
6.8
作者：
Hanlon CA;Dowdle LT;Gibson NB;Li X;Hamilton S;Canterberry M;Hoffman M
通讯作者：
Hoffman M
影响因子：
2.1
作者：
Christensen TE;Bang LE;Holmvang L;Hasbak P;Kjær A;Bech P;Østergaard SD
通讯作者：
Østergaard SD
影响因子：
7.6
作者：
Marhe, Reshmi;Luijten, Maartje;Franken, Ingmar H. A.
通讯作者：
Franken, Ingmar H. A.
影响因子：
17.7
作者：
Langleben, Daniel D.;Ruparel, Kosha;Childress, Anna R.
通讯作者：
Childress, Anna R.
影响因子：
3.4
作者：
Courtney KE;Schacht JP;Hutchison K;Roche DJ;Ray LA
通讯作者：
Ray LA