Biomarkers of chlorpyrifos exposure and effect in Egyptian cotton field workers.
Biomarkers of chlorpyrifos exposure and effect in Egyptian cotton field workers.
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埃及棉花野外工人暴露和效果的毒性生物标志物。
DOI：
10.1289/ehp.1002873
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发表时间：
2011-06
影响因子：
10.4
通讯作者：
Olson JR
中科院分区：
文献类型：
--
作者：
Farahat FM;Ellison CA;Bonner MR;McGarrigle BP;Crane AL;Fenske RA;Lasarev MR;Rohlman DS;Anger WK;Lein PJ;Olson JR
毒死蜱(CPF)是一种广泛使用的有机磷农药(OP)，其代谢产物为有效的胆碱酯酶(ChE)抑制剂CPF-Oxon和三氯-2-吡啶酚(TCPy)。尿TCPy通常被用作CPF暴露的生物标志物，而血液ChE活性被认为是CPF毒性的指标。然而，在每天反复接触OP的人群中，这些生物标志物是否与剂量有关还没有得到广泛的研究。我们试图确定反复接触CPF期间血ChE和尿TCPy之间的关系。从埃及梅努菲亚省的农药工人(n=38)身上采集每日尿样和每周血样，分别在棉田连续施药前、施药期间和施药后9-17天。我们比较了每个工人的血丁酰胆碱酯酶(BUCHE)和乙酰胆碱酯酶(AChE)活性与各自尿TCPY浓度。在1至2周CPF施用期中期，农药施用者的平均三氯苯丙氨酸水平(6,437μg/g肌酐)显著高于参与监督施药过程的技术人员(184μg/g)和工程师(157μg/g)。我们观察到尿TCPy与血BUCHE和AChE活性之间存在统计学上的显著负相关。暴露-效应关系的无效应水平(或拐点)的平均尿TCPy水平为：Buhe为114μg/g肌酐，AChE为3,161μg/g肌酐。我们的研究结果表明，在职业接触CPF的人群中，尿TCPy与血浆BUCHE和红细胞AChE之间存在剂量-效应关系。这些发现将有助于今后对中央公积金暴露的风险评估工作。
Chlorpyrifos (CPF), a widely used organophosphorus pesticide (OP), is metabolized to CPF-oxon, a potent cholinesterase (ChE) inhibitor, and trichloro-2-pyridinol (TCPy). Urinary TCPy is often used as a biomarker for CPF exposure, whereas blood ChE activity is considered an indicator of CPF toxicity. However, whether these biomarkers are dose related has not been studied extensively in populations with repeated daily OP exposures. We sought to determine the relationship between blood ChE and urinary TCPy during repeated occupational exposures to CPF. Daily urine samples and weekly blood samples were collected from pesticide workers (n = 38) in Menoufia Governorate, Egypt, before, during, and after 9–17 consecutive days of CPF application to cotton fields. We compared blood butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE) activities with the respective urinary TCPy concentrations in each worker. Average TCPy levels during the middle of a 1- to 2-week CPF application period were significantly higher in pesticide applicators (6,437 μg/g creatinine) than in technicians (184 μg/g) and engineers (157 μg/g), both of whom are involved in supervising the application process. We observed a statistically significant inverse correlation between urinary TCPy and blood BuChE and AChE activities. The no-effect level (or inflection point) of the exposure–effect relationships has an average urinary TCPy level of 114 μg/g creatinine for BuChE and 3,161 μg/g creatinine for AChE. Our findings demonstrate a dose–effect relationship between urinary TCPy and both plasma BuChE and red blood cell AChE in humans exposed occupationally to CPF. These findings will contribute to future risk assessment efforts for CPF exposure.
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影响因子：
5.8
作者：
ELLMAN, GL;COURTNEY, KD;FEATHERSTONE, RM
通讯作者：
FEATHERSTONE, RM
影响因子：
4.9
作者：
Farahat, TM;Abdelrasoul, GM;Anger, WK
通讯作者：
Anger, WK
影响因子：
10.4
作者：
Quandt, Sara A.;Chen, Haiying;Arcury, Thomas A.
通讯作者：
Arcury, Thomas A.
影响因子：
8.3
作者：
Barr, DB;Allen, R;Needham, LL
通讯作者：
Needham, LL
影响因子：
3.5
作者：
Arcury, Thomas A.;Grzywacz, Joseph G.;Quandt, Sara A.
通讯作者：
Quandt, Sara A.