Childhood adversity impacts on brain subcortical structures relevant to depression.
Childhood adversity impacts on brain subcortical structures relevant to depression.
复制标题
童年逆境对与抑郁症相关的大脑皮层下结构有影响。
DOI：
10.1016/j.jpsychires.2016.11.010
复制
发表时间：
2017-03
影响因子：
4.8
通讯作者：
Grabe HJ
中科院分区：
文献类型：
--
作者：
Frodl T;Janowitz D;Schmaal L;Tozzi L;Dobrowolny H;Stein DJ;Veltman DJ;Wittfeld K;van Erp TGM;Jahanshad N;Block A;Hegenscheid K;Völzke H;Lagopoulos J;Hatton SN;Hickie IB;Frey EM;Carballedo A;Brooks SJ;Vuletic D;Uhlmann A;Veer IM;Walter H;Schnell K;Grotegerd D;Arolt V;Kugel H;Schramm E;Konrad C;Zurowski B;Baune BT;van der Wee NJA;van Tol MJ;Penninx BWJH;Thompson PM;Hibar DP;Dannlowski U;Grabe HJ
童年期的逆境在抑郁症的发生发展中起着重要作用。MDD患者和健康对照组的皮层下脑结构存在差异，但童年逆境对MDD患者这种结构的具体影响仍不清楚。因此，本研究的目的是调查童年逆境是否与皮质下容量以及它如何与MDD和性别的诊断相互作用。在ENIGMA-MDD网络中，九所大学合作网站评估了MDD患者和对照组的儿童逆境和磁共振成像，参与了当前的联合大型分析。在这项全球范围内最大规模的研究中，研究人员利用FreeSurfer分析了3036名参与者的皮层下脑容量，以确定与儿童逆境相关的皮层下脑结构差异。一个显着的相互作用是显而易见的童年逆境，MDD诊断，性别和地区。增加暴露于童年逆境与较小的尾状核体积独立于MDD的女性。儿童期逆境的所有子类别与女性的尾状核体积呈负相关-特别是情感忽视和身体忽视（独立于年龄，ICV，成像部位和MDD诊断）。儿童期逆境和MDD诊断对皮质下脑容量无交互作用。童年时期的逆境是大脑结构异常的原因之一。它与皮质下大脑异常有关，这些异常与抑郁症等精神疾病有关。
Childhood adversity plays an important role for development of major depressive disorder (MDD). There are differences in subcortical brain structures between patients with MDD and healthy controls, but the specific impact of childhood adversity on such structures in MDD remains unclear. Thus, aim of the present study was to investigate whether childhood adversity is associated with subcortical volumes and how it interacts with a diagnosis of MDD and sex. Within the ENIGMA-MDD network, nine university partner sites, which assessed childhood adversity and magnetic resonance imaging in patients with MDD and controls, took part in the current joint mega-analysis. In this largest effort world-wide to identify subcortical brain structure differences related to childhood adversity, 3036 participants were analyzed for subcortical brain volumes using FreeSurfer. A significant interaction was evident between childhood adversity, MDD diagnosis, sex, and region. Increased exposure to childhood adversity was associated with smaller caudate volumes in females independent of MDD. All subcategories of childhood adversity were negatively associated with caudate volumes in females - in particular emotional neglect and physical neglect (independently from age, ICV, imaging site and MDD diagnosis). There was no interaction effect between childhood adversity and MDD diagnosis on subcortical brain volumes. Childhood adversity is one of the contributors to brain structural abnormalities. It is associated with subcortical brain abnormalities that are relevant to psychiatric disorders such as depression.
登录
查看更多内容
影响因子：
3.3
作者：
Cowell RA;Cicchetti D;Rogosch FA;Toth SL
通讯作者：
Toth SL
影响因子：
56.9
作者：
Santarelli, L;Saxe, M;Hen, R
通讯作者：
Hen, R
影响因子：
--
作者：
Edmiston, Erin E.;Wang, Fei;Mazure, Carolyn M.;Guiney, Joanne;Sinha, Rajita;Mayes, Linda C.;Blumberg, Hilary P.
通讯作者：
Blumberg, Hilary P.
影响因子：
7.6
作者：
Everaerd, Daphne;Klumpers, Floris;Tendolkar, Indira
通讯作者：
Tendolkar, Indira
影响因子：
4.8
作者：
Bernstein, DP;Stein, JA;Zule, W
通讯作者：
Zule, W