Bronchial hyperreactivity is associated with enhanced grain dust-induced airflow obstruction.
Bronchial hyperreactivity is associated with enhanced grain dust-induced airflow obstruction.
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支气管高反应性与谷物粉尘引起的气流阻塞增强有关。
DOI：
10.1152/jappl.2000.89.3.1172
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Schwartz,DA
中科院分区：
文献类型：
--
作者：
Kline,JN;Jagielo,PJ;Watt,JL;Schwartz,DA
支气管高反应性(BHR)与哮喘中呼吸道炎症的存在有关，并见于职业接触谷物粉尘的个人。为了更好地了解谷物粉尘暴露后BHR与肺部炎症的关系，我们对7名BHR患者进行了玉米粉尘提取物的吸入刺激[1 S用力呼气量(FEV1)比FEV1减少20%或更多，累积组胺≤47.3呼吸单位]，并与7名匹配的对照组进行了生理和炎症反应的比较。BHR受试者暴露于可耐受的雾化吸入CDE(目标剂量为0.16μg/kg内毒素)；匹配的对照组接受等量的CDE。BHR受试者在吸入CDE后2小时内主诉胸闷和呼吸困难的频率明显高于对照组。同样，患有BHR的受试者在暴露于CDE后4小时的时间点上，FEV1的百分比下降幅度明显更大。吸入镉后4h，所有受试者支气管肺泡灌洗液中细胞总数、中性粒细胞、肿瘤坏死因子-α、白介素6、白介素8均显著升高，但对照组与高氧组间差异无统计学意义。这些结果表明，尽管患有BHR的受试者在暴露于CDE后FEV1下降更剧烈，但对CDE的炎症反应在患有BHR的受试者和没有BHR的受试者中是相似的。
Bronchial hyperreactivity (BHR) is associated with the presence of airway inflammation in asthma and is seen in individuals occupationally exposed to grain dust. To better understand the relationship between BHR and pulmonary inflammation after grain dust exposure, we carried out an inhalation challenge to corn dust extract (CDE) on seven subjects with BHR [a 20% or greater decrease in forced expiratory volume in 1 s (FEV1) compared with diluent FEV1with a cumulative dose of histamine ≤47.3 breath units] and compared their physiological and inflammatory responses with those of seven matched control subjects. BHR subjects were exposed to nebulized CDE (target dose of 0.16 μg/kg endotoxin) as tolerated; matched controls received equal amounts of CDE. Subjects with BHR complained of chest tightness and dyspnea within the 2 h after inhalation of CDE significantly more frequently than controls. Similarly, subjects with BHR developed significantly greater percent declines in FEV1at time points up to 4 h after exposure to CDE. Significant increases in total cells, neutrophils, tumor necrosis factor-α, interleukin-6, and interleukin-8 were detected in bronchoalveolar lavage fluid 4 h after inhalation of CDE in all subjects, but no differences were detected between the control and BHR groups. These results suggest that, although subjects with BHR develop a more precipitous decline in FEV1after exposure to CDE, the inflammatory response to CDE is similar in subjects with and without BHR.
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组胺早期释放和内毒素导致的死亡
DOI：
10.3181/00379727-137-35690
发表时间：
1971
影响因子：
--
作者：
J. Vick;Ben Mehlman;M. Heiffer
通讯作者：
M. Heiffer
影响因子：
9.6
作者：
CLAPP, WD;THORNE, PS;SCHWARTZ, DA
通讯作者：
SCHWARTZ, DA
DOI：
10.1080/00039896.1981.10667610
发表时间：
1981-01-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
CHANYEUNG, M;SCHULZER, M;GRZYBOWSKI, S
通讯作者：
GRZYBOWSKI, S
谷物粉尘暴露导致中性粒细胞募集至肺部的机制。
DOI：
10.1164/ajrccm/138.4.921
发表时间：
1988
期刊：
The American review of respiratory disease
影响因子：
--
作者：
S. V. Essen;R. Robbins;Austin B. Thompson;R. Ertl;J. Linder;J. Linder;S. Rennard
通讯作者：
S. Rennard
影响因子：
3.3
作者：
MICHEL, O;DUCHATEAU, J;SERGYSELS, R
通讯作者：
SERGYSELS, R