The association of reproductive stage with lobular cerebellar network connectivity across female adulthood.
The association of reproductive stage with lobular cerebellar network connectivity across female adulthood.
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DOI：
10.1016/j.neurobiolaging.2022.05.014
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发表时间：
2022-09
影响因子：
4.2
通讯作者：
Bernard, Jessica A.
中科院分区：
文献类型：
--
作者：
Ballard, Hannah K.;Jackson, T. Bryan;Hicks, Tracey H.;Bernard, Jessica A.
小脑老化的性别差异可能与绝经期激素变化有关。我们使用来自剑桥老龄化和神经科学中心的数据库评估了生殖阶段和小叶小脑网络连接之间的关联。我们使用了原始的结构和静息状态神经影像学数据以及关于年龄、性别和绝经相关变量的信息。第一级和第二级以及第五级和第六级小叶是我们感兴趣的小脑种子。我们使用生殖衰老阶段研讨会标准表征生殖阶段。结果表明，绝经后女性有较低的小脑-纹状体和小脑-皮质连接，特别是在额叶区域，沿着与小脑内的连接较低，生育女性相比。绝经后的女性在某些大脑区域也表现出更大的连通性。差异开始出现在更年期的过渡阶段。此外，研究结果揭示了女性生殖组和年龄匹配的男性对照组之间的连接性的性别特异性差异。这表明更年期可能与老年女性的小脑网络连接有关，衰老大脑的性别差异可能与这一生物学过程有关。
Sex-specific differences in the aging cerebellum may be related to hormone changes with menopause. We evaluated the association between reproductive stage and lobular cerebellar network connectivity using data from the Cambridge Centre for Ageing and Neuroscience repository. We used raw structural and resting state neuroimaging data and information regarding age, sex, and menopause-related variables. Crus I and II and Lobules V and VI were our cerebellar seeds of interest. We characterized reproductive stage using the Stages of Reproductive Aging Workshop criteria. Results show that postmenopausal females have lower cerebello-striatal and cerebello-cortical connectivity, particularly in frontal regions, along with lower connectivity within the cerebellum, compared to reproductive females. Postmenopausal females also exhibit greater connectivity in some brain areas as well. Differences begin to emerge across transitional stages of menopause. Further, results reveal sex-specific differences in connectivity between female reproductive groups and age-matched male control groups. This suggests that menopause may be associated with cerebellar network connectivity in aging females, and sex differences in the aging brain may be related to this biological process.
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影响因子：
4.8
作者：
Bernard, Jessica A.;Leopold, Daniel R.;Calhoun, Vince D.;Mittal, Vijay A.
通讯作者：
Mittal, Vijay A.
影响因子：
3.5
作者：
Carter, Christine L.;Resnick, Eileen M.;Kalbarczyk, Anna
通讯作者：
Kalbarczyk, Anna
影响因子：
4.2
作者：
Busatto, GF;Garrido, GEJ;Bottino, CM
通讯作者：
Bottino, CM
影响因子：
5.7
作者：
Diedrichsen, Joern;Balsters, Joshua H.;Ramnani, Narender
通讯作者：
Ramnani, Narender
影响因子：
11
作者：
Boggio, P. S.;Khoury, L. P.;Fregni, F.
通讯作者：
Fregni, F.