African swine fever: A re-emerging viral disease threatening the global pig industry.
African swine fever: A re-emerging viral disease threatening the global pig industry.
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DOI：
10.1016/j.tvjl.2017.12.025
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Dixon LK
中科院分区：
文献类型：
--
作者：
Sánchez-Cordón PJ;Montoya M;Reis AL;Dixon LK
在欧洲流行的基因II型非洲猪瘟病毒（ASFV）对家猪和野猪具有很高的致病性。欧洲的基因型II ASFV毒株不表现出减毒，并且建立持续感染的能力有限。东欧的野猪种群在ASFV的维持和传播中起着重要作用。针对ASFV的免疫应答尚未完全了解，阻碍了疫苗的合理设计。控制措施依赖于“淘汰”政策和对生猪流动的控制，这对受影响地区产生了重大影响。非洲猪瘟（ASF）最近已从撒哈拉以南非洲蔓延到外高加索地区、俄罗斯联邦部分地区和东欧。在这种新的流行病学情况下，与非洲的情况相比，这种疾病有相似之处，但也有重要的不同之处，包括野猪的大量参与。更好地了解这一新情况将有助于更好地控制和预防疾病的进一步传播。在这篇文章中，这些不同的情况进行了比较，并介绍了ASF病毒株的发病机制，感染的免疫反应和疫苗开发的前景的最新信息。知识差距和未来的控制前景进行了讨论。
Genotype II African swine fever virus (ASFV) circulating in Europe has high pathogenicity for domestic pigs and wild boar. Genotype II ASFV strains in Europe do not exhibit attenuation and have limited ability to establish persistent infections. The wild boar population in Eastern Europe plays an important role in the maintenance and spread of ASFV. Immune responses against ASFV are not fully understood, hampering the rational design of vaccines. Control relies on ‘stamping-out’ policies and control of pig movements, which have a significant impact on affected regions. African swine fever (ASF) recently has spread beyond sub-Saharan Africa to the Trans-Caucasus region, parts of the Russian Federation and Eastern Europe. In this new epidemiological scenario, the disease has similarities, but also important differences, compared to the situation in Africa, including the substantial involvement of wild boar. A better understanding of this new situation will enable better control and prevent further spread of disease. In this article, these different scenarios are compared, and recent information on the pathogenesis of ASF virus strains, the immune response to infection and prospects for developing vaccines is presented. Knowledge gaps and the prospects for future control are discussed.
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影响因子：
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