Interconnecting gold islands with DNA origami nanotubes.

Interconnecting gold islands with DNA origami nanotubes.
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DOI:
10.1021/nl1033073
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发表时间:
2010-12-08
期刊:
影响因子:
10.8
通讯作者:
Yan H
Yan H
中科院分区:
材料科学1区
文献类型:
--
作者:
Ding B;Wu H;Xu W;Zhao Z;Liu Y;Yu H;Yan H

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支架式 DNA 折纸最近成为一种多功能、可编程的方法,可将 DNA 折叠成任意形状的纳米结构,这些纳米结构可在空间上寻址,分辨率低于 10 nm。对于功能性 DNA 纳米技术来说,关键挑战之一是将 DNA 折纸自下而上的自组装与用于生成表面图案的自上而下的光刻方法相结合。在本报告中,我们证明了两端附近带有多个硫醇基团修饰的固定长度 DNA 折纸纳米管可用于连接通过电子束光刻 (EBL) 制造的表面图案化金岛(直径数十纳米)。原子力显微成像证实 DNA 折纸纳米管可以在具有不同岛间距离和相对位置的金岛之间有效排列。这一发展代表着在连接自下而上和自上而下组装方法的目标方面取得了进展。
Scaffolded DNA origami has recently emerged as a versatile, programmable method to fold DNA into arbitrarily shaped nanostructures that are spatially addressable, with sub-10 nm resolution. Toward functional DNA nanotechnology, one of the key challenges is to integrate the bottom up self-assembly of DNA origami with the top-down lithographic methods used to generate surface patterning. In this report we demonstrate that fixed length DNA origami nanotubes, modified with multiple thiol groups near both ends, can be used to connect surface patterned gold islands (tens of nanometers in diameter) fabricated by electron beam lithography (EBL). Atomic force microscopic imaging verified that the DNA origami nanotubes can be efficiently aligned between gold islands with various inter-island distances and relative locations. This development represents progress toward the goal of bridging bottom up and top down assembly approaches.
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