The association between interleukin-1β gene polymorphisms and the risk of breast cancer: a systematic review and meta-analysis.
The association between interleukin-1β gene polymorphisms and the risk of breast cancer: a systematic review and meta-analysis.
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DOI：
10.5114/aoms/99839
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Yuan F
中科院分区：
文献类型：
--
作者：
Wang B;Yuan F
研究表明，白细胞介素-1 β（IL-1β）基因多态性与乳腺癌发病风险密切相关。然而，结果仍然存在争议。在PubMed、Embase和Web of Science数据库中检索了截至2018年6月的合格已发表文章。比值比和95%置信区间用于确定IL-1β基因多态性与乳腺癌风险之间的潜在联系。从我们的结果中，我们发现IL-1β的三种常见多态性（rs 16944，rs 1143634，rs 1143627）在所有遗传模型中与乳腺癌风险无显著相关性。根据种族亚组分析，rs 16944多态性在亚洲人中的隐性模型和杂合子模型中患乳腺癌的风险更高（TT vs. CC+CT：1.229，95% CI：1.063-1.422，p = 0.005; TT vs. CT：1.211，95% CI：1.057-1.388，p = 0.006）。对于rs 1143627多态性，仅在亚洲人的显性模型中观察到乳腺癌风险显著降低（CT+TT vs. CC：OR = 0.944，95% CI：0.897-0.994，p = 0.027）。在根据绝经状态对患者进行分层后，我们发现rs 1143627多态性在三种基因型模型中与绝经后妇女乳腺癌风险降低相关：等位基因模型、隐性模型和纯合子模型（T与C：0.859，95% CI：0.753-0.98，p = 0.024; TT与CC+CT：0.727，95% CI：0.576-0.918，p = 0.007; TT与CC：0.743，95% CI：0.626-0.882，p = 0.001）。与参考对照来源和基因分型方法的其他分析一样，IL-1β多态性与乳腺癌风险之间没有显着相关性。rs 16944和rs 1143627多态性分别仅在亚洲人和绝经后妇女中与乳腺癌风险显著相关。
It is reported that there is a close association between interleukin-1β (IL-1β) gene polymorphisms and breast cancer risk. However, the results remain controversial. Eligible published articles were searched in PubMed, Embase, and Web of Science databases up to June 2018. Odds ratios with 95% confidence intervals were used to identify potential links between IL-1β genetic polymorphisms and the risk of breast cancer. From our results, we found that three common polymorphisms in IL-1β (rs16944, rs1143634, rs1143627) had no significant associations with breast cancer risk in all genetic models. Based on the analysis from ethnic subgroups, there was a higher risk of breast cancer for rs16944 polymorphism in the recessive model and heterozygous model among Asians (TT vs. CC+CT: 1.229, 95% CI: 1.063–1.422, p = 0.005; TT vs. CT: 1.211, 95% CI: 1.057–1.388, p = 0.006). For the rs1143627 polymorphism, a significantly decreased breast cancer risk was observed in the dominant model only in Asians (CT+TT vs. CC: OR = 0.944, 95% CI: 0.897–0.994, p = 0.027). After stratifying patients according to the menopausal state, we found that polymorphism of rs1143627 correlated with reduced breast cancer risk among post-menopausal women in three genotype models: allele, recessive model and homozygous model (T vs C: 0.859, 95% CI: 0.753–0.98, p = 0.024; TT vs. CC+CT: 0.727, 95% CI: 0.576–0.918, p = 0.007; TT vs. CC: 0.743, 95% CI: 0.626–0.882, p = 0.001). As for other analyses with reference to source of controls and genotyping methods, no significant association between IL-1β polymorphism and breast cancer risk was demonstrated. The rs16944 and rs1143627 polymorphisms are significantly associated with the risk of breast cancer only in Asian people and in post-menopausal women respectively.
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影响因子：
11.5
作者：
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通讯作者：
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DOI：
10.5114/aoms.2017.68942
发表时间：
2017-08
期刊：
Archives of medical science : AMS
影响因子：
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DOI：
10.5114/aoms.2018.73345
发表时间：
2018-10
期刊：
Archives of medical science : AMS
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DOI：
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影响因子：
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