Association of interleukin-17a rs2275913 gene polymorphism and asthma risk: a meta-analysis.
Association of interleukin-17a rs2275913 gene polymorphism and asthma risk: a meta-analysis.
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DOI：
10.5114/aoms.2018.73345
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Li M
中科院分区：
文献类型：
--
作者：
Zhai C;Li S;Feng W;Shi W;Wang J;Wang Q;Chai L;Zhang Q;Yan X;Li M
白细胞介素-17A（IL-17A）是一种促炎细胞因子，在哮喘的发病机制中起重要作用。许多研究调查了IL-17A rs2275913多态性与哮喘风险之间的关系。然而，所获得的结果是不确定的。本荟萃分析的目的是阐明IL-17A rs2275913多态性与哮喘风险之间的关系。检索在PubMed、Web of Science、Elsevier、Google Scholar、万方和中国知网（CNKI）数据库中进行，数据由两名独立评审员从合格研究中提取。计算合并比值比（OR）和相应的95%置信区间（CI）。还评估了发表偏倚、异质性和敏感性分析。纳入了10项研究，共计5016例受试者。总体而言，结果表明IL-17 A rs2275913多态性与哮喘风险之间存在显著相关性（G vs. A：OR = 0.866，95% CI：0.789 - 0.951，p = 0.003; GG + GA vs. AA：OR = 0.752，95% CI：0.633 - 0.895，p = 0.001）。在按年龄和种族进行的亚组分析中，IL-17A中rs2275913的G等位基因与儿童和亚洲人哮喘风险降低显著相关。这项荟萃分析的结果表明，IL-17A中rs2275913的G等位基因是哮喘发生的保护因素。
Interleukin-17A (IL-17A), a pro-inflammatory cytokine, plays an important role in the pathogenesis of asthma. A number of studies have investigated the relationship between IL-17A rs2275913 polymorphism and risk of asthma. However, the results obtained are inconclusive. The aim of this meta-analysis is to clarify the relationship between IL-17A rs2275913 polymorphism and asthma risk. Searches were conducted in PubMed, Web of Science, Elsevier, Google Scholar, Wanfang and Chinese National Knowledge Infrastructure (CNKI) databases, and data were extracted from eligible studies by two independent reviewers. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated. Publication bias, heterogeneity and sensitivity analysis were also assessed. Ten studies with a total of 5016 subjects were included. Overall, the results indicated a significant association between the IL-17A rs2275913 polymorphism and the risk of asthma (G vs. A: OR = 0.866, 95% CI: 0.789–0.951, p = 0.003; GG+GA vs. AA: OR = 0.752, 95% CI: 0.633–0.895, p = 0.001). In subgroup analysis by age and ethnicity, the G allele of rs2275913 in IL-17A was significantly associated with a reduced risk of asthma in children and Asians. The results of this meta-analysis indicate that the G allele of rs2275913 in IL-17A is a protective factor for the development of asthma.
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影响因子：
24.3
作者：
Laan, M;Prause, O;Lindén, A
通讯作者：
Lindén, A
影响因子：
3.2
作者：
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通讯作者：
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影响因子：
9.1
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.12659/msm.895494
发表时间：
2016-03-08
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
--
作者：
Du J;Han JC;Zhang YJ;Qi GB;Li HB;Zhang YJ;Cai S
通讯作者：
Cai S