Histological Evaluation of Porous Additive-Manufacturing Titanium Artificial Bone in Rat Calvarial Bone Defects.
Histological Evaluation of Porous Additive-Manufacturing Titanium Artificial Bone in Rat Calvarial Bone Defects.
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DOI：
10.3390/ma14185360
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发表时间：
2021-09-17
期刊：
影响因子：
--
通讯作者：
Ueno T
中科院分区：
文献类型：
--
作者：
Imagawa N;Inoue K;Matsumoto K;Omori M;Yamamoto K;Nakajima Y;Kato-Kogoe N;Nakano H;Thi Minh Le P;Yamaguchi S;Ueno T
使用增材制造钛人工骨（AMTAB）进行颌骨重建最近引起了相当大的关注。钛人工骨的合成基于手术前获得的三维计算机断层扫描图像。对多孔AMTAB（pAMTAB）包埋在大鼠颅骨缺损中进行了组织学评价。本研究检查了三组：植入混合酸和热处理的pAMTAB的大鼠，植入未处理的pAMTAB的大鼠，以及未植入的大鼠。在两个pAMTAB组中，使用5 mm环钻棒在大鼠颅骨中创建骨缺损，然后植入pAMTAB。使用周围骨的配合力将pAMTAB固定到缺损处。在植入后4、8和16周处死大鼠，解剖颅骨。制备未脱钙研磨载玻片，并使用Villanueva Goldner染色。与无种植体对照组相比，两个pAMTAB组均表现出缺损内新骨形成，混合酸和热处理的pAMTAB组的骨形成大于未处理的pAMTAB组，但差异不显著。这些数据表明，pAMTAB在骨缺损中植入后诱导骨形成。骨形成似乎通过先前的混合酸和热处理的pAMTAB增强。
Jaw reconstruction using an additive-manufacturing titanium artificial bone (AMTAB) has recently attracted considerable attention. The synthesis of a titanium artificial bone is based on three-dimensional computed tomography images acquired before surgery. A histological evaluation of porous AMTAB (pAMTAB) embedded in rat calvarial bone defects was conducted. This study examined three groups: rats implanted with mixed-acid and heat-treated pAMTAB, rats implanted with untreated pAMTAB, and rats with no implant. In both pAMTAB groups, bone defects were created in rat calvarial bones using a 5-mm trephine bar, followed by pAMTAB implantation. The pAMTAB was fixed to the defect using the fitting force of the surrounding bones. The rats were sacrificed at 4, 8, and 16 weeks after implantation, and the skull was dissected. Undecalcified ground slides were prepared and stained with Villanueva Goldner. Compared with the no implant control group, both pAMTAB groups exhibited new bone formation inside the defect, with greater bone formation in the mixed-acid and heat-treated pAMTAB group than in the untreated pAMTAB group, but the difference was not significant. These data suggest that pAMTAB induces bone formation after implantation in bone defects. Bone formation appears to be enhanced by prior mixed-acid and heat-treated pAMTAB.
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影响因子：
3.9
作者：
Yamamoto, Kayoko;Yamaguchi, Seiji;Matsushita, Tomiharu;Mori, Shigeo;Hirata, Azumi;Kato-Kogoe, Nahoko;Nakano, Hiroyuki;Nakajima, Yoichiro;Nishitani, Yoshihiro;Nagatsuka, Hitoshi;Ueno, Takaaki
通讯作者：
Ueno, Takaaki
影响因子：
--
作者：
Koch, JC
通讯作者：
Koch, JC
放电等离子烧结多孔Ti-6Al-4V合金仿生表面改性
DOI：
10.1002/jbm.b.20004
发表时间：
2004-01-15
影响因子：
3.4
作者：
Kon, M;Hirakata, LM;Asaoka, K
通讯作者：
Asaoka, K
类似于人类松质骨的生物活性钛金属：通过选择性激光熔化和化学处理制造
影响因子：
9.7
作者：
Pattanayak, Deepak K.;Fukuda, A.;Kokubo, T.
通讯作者：
Kokubo, T.
DOI：
10.1002/jbm.b.10530
发表时间：
2003-02-15
影响因子：
3.4
作者：
Assad, M;Jarzem, P;Rivard, CH
通讯作者：
Rivard, CH