Osteogenic capacity of mixed-acid and heat-treated titanium mesh prepared by a selective laser melting technique.
Osteogenic capacity of mixed-acid and heat-treated titanium mesh prepared by a selective laser melting technique.
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DOI：
10.1039/c8ra04193h
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发表时间：
2018-07-19
期刊：
影响因子：
3.9
通讯作者：
Ueno, Takaaki
中科院分区：
文献类型：
--
作者：
Yamamoto, Kayoko;Yamaguchi, Seiji;Matsushita, Tomiharu;Mori, Shigeo;Hirata, Azumi;Kato-Kogoe, Nahoko;Nakano, Hiroyuki;Nakajima, Yoichiro;Nishitani, Yoshihiro;Nagatsuka, Hitoshi;Ueno, Takaaki
使用添加剂制造人工骨作为修复复杂骨缺损的材料的实际应用目前引起了人们的关注。在这项研究中，我们比较了由Kokubo等人开发的方法合成的材料的成骨能力。用硫酸和盐酸的混合物处理3D打印的钛(钛)网，并用经过常规化学处理的材料进行加热(混酸和热处理)。用这种方法处理的钛板被发现在植入兔胫骨缺损处时，可以促进其表面高度活跃的骨形成。以前没有研究将这种方法与其他表面处理方法进行比较。在这项研究中，我们利用组织学和其他观察方法比较了选择性激光熔融技术(SLM)制备的钛网状物和经混合酸和热处理的钛网状物和经常规化学钛表面处理的钛网状物植入大鼠颅骨骨缺损模型中的骨形成过程。我们发现，无论是微型计算机断层扫描还是未脱钙的切片观察都表明，用混合酸和热处理的网状物植入的大鼠骨形成最好。我们的结果提示，用SLM制备的混酸和热处理的钛网可能在骨缺损中具有较高的成骨能力。使用添加剂制造人工骨作为修复复杂骨缺损的材料的实际应用目前引起了人们的关注。
The practical use of additive manufacturing to create artificial bone as a material for repairing complex bone defects is currently attracting attention. In this study, we compared the osteogenic capacity of materials composited by the method developed by Kokubo et al. of treating 3D-printed titanium (Ti) mesh with a mixture of H2SO4 and HCl and heating (mixed-acid and heat treatment) with that of materials subjected to conventional chemical treatment. Ti plates treated with this method have been found to promote highly active bone formation on their surface when inserted into rabbit tibial bone defects. No previous study has compared this method with other surface treatment methods. In this study, we used histological and other observations to compare the bone formation process in bone defects when Ti meshes prepared by the selective laser melting technique (SLM) and treated either with mixed acids and heat or with conventional chemical Ti surface treatments were implanted in a rat calvarial bone defect model. We found that both micro-computed tomography and observations of undecalcified ground sections showed that the best bone formation was observed in rats implanted with mesh treated with mixed acids and heat. Our results suggest that mixed-acid and heat-treated Ti mesh prepared by SLM may have a high osteogenic capacity in bone defects. The practical use of additive manufacturing to create artificial bone as a material for repairing complex bone defects is currently attracting attention.
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DOI：
10.1016/j.tripleo.2008.12.018
发表时间：
2009-04-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
--
作者：
Iino, Mitsuyoshi;Fukuda, Masayuki;Takato, Tsuyoshi
通讯作者：
Takato, Tsuyoshi
影响因子：
2
作者：
Karaji, Zahra Gorgin;Houshmand, Behzad;Faghihi, Shahab
通讯作者：
Faghihi, Shahab
通过简单的化学和热处理制备的带正电的生物活性钛金属
影响因子：
3.9
作者：
Kokubo, Tadashi;Pattanayak, Deepak K.;Nakamura, Takashi
通讯作者：
Nakamura, Takashi
影响因子：
4.3
作者：
Becker, W;Becker, BE;Reid, T
通讯作者：
Reid, T
影响因子：
14
作者：
Takemoto, M;Fujibayashi, S;Nakamura, T
通讯作者：
Nakamura, T