Effect of COVID-19 on Male Reproductive System - A Systematic Review.
Effect of COVID-19 on Male Reproductive System - A Systematic Review.
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DOI：
10.3389/fendo.2021.677701
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发表时间：
2021
影响因子：
5.2
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
He Y;Wang J;Ren J;Zhao Y;Chen J;Chen X
血管紧张素转换酶II（ACE 2）是严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）进入宿主细胞的受体，广泛表达于睾丸和前列腺组织。睾丸和前列腺产生精液。目前，关于SARS-CoV-2是否可以存在于感染男性的精液中，有相互矛盾的报道。全面概述COVID-19是否会影响男性生殖系统。我们回顾了2019冠状病毒病（COVID-19）对男性生殖系统可能影响的相关出版物，并总结了迄今为止最新和最重要的研究成果。纳入了2019年12月至2021年1月31日期间以英文发表的关于精液、睾丸和前列腺液中存在SARS-CoV-2以及COVID-19对男性生殖影响的文献。我们确定了28项相关研究，其中只有一项报告了精液中存在SARS-CoV-2。研究发现，中度感染患者的精液质量低于轻度感染患者和健康对照组。精液质量受损可能与发烧和炎症有关。睾丸/附睾病理分析显示10例睾丸标本SARS-CoV-2病毒颗粒阳性，睾丸生精功能受损。所有94份前列腺液（EPS）样本均为SARS-CoV-2 RNA阴性。COVID-19患者精液中存在SARS-CoV-2的可能性非常小，精液很少被视为SARS-CoV-2遗传物质的携带者。然而，COVID-19可能通过免疫或炎症反应导致睾丸生精功能障碍。对于COVID-19男性患者和在父亲感染期间怀孕的胎儿，需要进行长期随访。
Angiotensin-converting enzyme II (ACE2), a receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) to enter host cells, is widely expressed in testes and prostate tissues. The testis and prostate produce semen. At present, there are contradictory reports about whether SARS-CoV-2 can exist in the semen of infected men. To provide a comprehensive overview of the topic of whether COVID-19 can impact on male reproductive system. We reviewed the relevant publications on the possible impact of Coronavirus Disease 2019 (COVID-19) on male reproductive system and summarized the latest and most important research results so far. Literature published in English from December 2019 to January 31, 2021 regarding the existence of SARS-CoV-2 in semen, testis, and prostatic fluid and the effects of COVID-19 on male reproductive were included. We identified 28 related studies, only one of which reported the presence of SARS-CoV-2 in semen. The study found that the semen quality of patients with moderate infection was lower than that of patients with mild infection and healthy controls. The impaired semen quality may be related to fever and inflammation. Pathological analysis of the testis/epididymis showed that SARS-CoV-2 viral particles were positive in 10 testicular samples, and the spermatogenic function of the testis was impaired. All 94 expressed prostatic secretion (EPS) samples were negative for SARS-CoV-2 RNA. The likelihood of SARS-CoV-2 in the semen of COVID-19 patients is very small, and semen should rarely be regarded as a carrier of SARS-CoV-2 genetic material. However, COVID-19 may cause testicular spermatogenic dysfunction via immune or inflammatory reactions. Long-term follow-up is needed for COVID-19 male patients and fetuses conceived during the father’s infection period.
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DOI：
10.1177/0394632017726261
发表时间：
2017-09
影响因子：
3.5
作者：
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通讯作者：
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影响因子：
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