Combining molecular typing and spatial pattern analysis to identify areas of high tuberculosis transmission in a moderate-incidence county in Taiwan.
Combining molecular typing and spatial pattern analysis to identify areas of high tuberculosis transmission in a moderate-incidence county in Taiwan.
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结合分子分型和空间模式分析来确定台湾中等发病县的结核病高传播区域。
DOI：
10.1038/s41598-017-05674-6
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发表时间：
2017-07-14
影响因子：
4.6
通讯作者：
Dou HY
中科院分区：
文献类型：
--
作者：
Chen YY;Chang JR;Wu CD;Yeh YP;Yang SJ;Hsu CH;Lin MC;Tsai CF;Lin MS;Su IJ;Dou HY
本研究从2012年1月至12月在台湾中部收集的303例临床结核分枝杆菌（MTB）患者中随机抽取303株进行检测。主要系为北京系（N = 114, 37.62%）、哈勒姆系（N = 76, 25.08%）和东非-印度系（N = 42, 13.86%）。值得注意的是，年轻人（≤30岁）感染北京基因型的可能性是老年人（≥70岁）的6.58倍（p < 0.05）。结合分子分型方法和地理信息系统（GIS）分析，发现北京菌株在热点地区的发病率（33%）比非热点地区的发病率（17%）高2倍。通过24 MIRU-VNTR分型，聚集性人群感染北京菌株的可能性是非聚集性人群的1.96倍，提示MTB是近期传播和出现的。最后，我们观察到随着所分析的环境因素的密度/浓度的增加，结核病发病率呈上升趋势，表明环境因素与结核病传播有关；然而，只有人口密度与结核病风险增加显著相关（p < 0.05）。分子分型方法结合空间分析提示可能存在结核传播。阻断传播的早期干预如果针对结核病热区，可能最为有效。
In total, 303 randomly selected clinical Mycobacterium tuberculosis (MTB) isolates from 303 patients (collected January to December 2012) in central Taiwan were examined. The major lineages found were Beijing (N = 114, 37.62%), Haarlem (N = 76, 25.08%) and East African–Indian (EAI) (N = 42, 13.86%). Notably, younger persons (≤30 years old) were 6.58 times more likely to be infected with a Beijing genotype compared to older persons (>70 years) (p < 0.05). Combining molecular typing methods and geographical information system (GIS) analysis, we uncovered a twofold higher incidence of Beijing strains in a hotspot area (33%) compared to non-hotspot areas (17%). By 24 MIRU-VNTR typing, persons in clustered groups were 1.96 times more likely to be infected with a Beijing strain compared with non-clustered persons, suggesting recent spread and emergence of MTB. Finally, we observed a trend in which TB incidence increased as the density/concentration of analyzed environmental factors increased, suggesting that environmental factors are associated with TB transmission; however, only population density was found to be significantly associated with increased risk of TB (p < 0.05). Molecular typing methods combined with spatial analysis suggest possible TB transmission. Early intervention to interrupt transmission may be most effective if targeted to hot zones of TB.
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影响因子：
3.7
作者：
Nguyen VA;Choisy M;Nguyen DH;Tran TH;Pham KL;Thi Dinh PT;Philippe J;Nguyen TS;Ho ML;Van Tran S;Bañuls AL;Dang DA
通讯作者：
Dang DA
影响因子：
3.7
作者：
Dou HY;Tseng FC;Lin CW;Chang JR;Sun JR;Tsai WS;Lee SY;Su IJ;Lu JJ
通讯作者：
Lu JJ
DOI：
10.1054/tuld.1998.0003
发表时间：
1998-01-01
期刊：
Tubercle and Lung Disease
影响因子：
--
作者：
Kurepina, N. E.;Sreevatsan, S.;Kreiswirth, Barry N.
通讯作者：
Kreiswirth, Barry N.
影响因子：
3.7
作者：
Chen YY;Chang JR;Kuo SC;Tseng FC;Huang WC;Huang TS;Chen YS;Chiueh TS;Sun JR;Su IJ;Dou HY
通讯作者：
Dou HY
影响因子：
9.4
作者：
Shamputa, Isdore Chola;Lee, Jongseok;Barry, Clifton E., III
通讯作者：
Barry, Clifton E., III