Disentangling the influences of multiple thalamic nuclei on prefrontal cortex and cognitive control.
Disentangling the influences of multiple thalamic nuclei on prefrontal cortex and cognitive control.
复制标题
理清多个丘脑核团对前额叶皮层及认知控制的影响
DOI：
10.1016/j.neubiorev.2021.06.042
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发表时间：
2021-09
影响因子：
8.2
通讯作者：
Saalmann YB
中科院分区：
文献类型：
--
作者：
Phillips JM;Kambi NA;Redinbaugh MJ;Mohanta S;Saalmann YB
前额叶皮质（PFC）与丘脑有着复杂的关系，涉及许多沿其前后范围主要占据内侧区域的核团。这些核团中的大多数丘脑皮质神经元受到通过基底神经节汇聚的情感和认知信号的调节。我们综述了与PFC相连的丘脑核团可能如何对认知控制的各个方面做出贡献：从内部状态和目标信息的处理，促进其与记忆信息以及刺激和行为的习得价值的相互作用，到它们对高级认知过程、注意力分配和目标导向行为的影响。这包括对诸如规则到选择（小细胞背内侧核）、价值到选择（大细胞背内侧核）、记忆到选择（前内侧核）和感觉信息到选择（内侧枕核）等转换的作用。常见的机制似乎是丘脑对皮质增益和皮质 - 皮质功能连接性的调节。解剖结构也暗示内侧PFC在调节涉及其他眶额和外侧PFC区域的丘脑皮质回路的处理过程中具有独特作用。我们进一步讨论了皮质 - 基底神经节回路如何可能提供一种机制，通过该机制PFC控制皮质 - 皮质功能连接性。
The prefrontal cortex (PFC) has a complex relationship with the thalamus, involving many nuclei which occupy predominantly medial zones along its anterior-to-posterior extent. Thalamocortical neurons in most of these nuclei are modulated by the affective and cognitive signals which funnel through the basal ganglia. We review how PFC-connected thalamic nuclei likely contribute to all aspects of cognitive control: from the processing of information on internal states and goals, facilitating its interactions with mnemonic information and learned values of stimuli and actions, to their influence on high-level cognitive processes, attentional allocation and goal-directed behavior. This includes contributions to transformations such as rule-to-choice (parvocellular mediodorsal nucleus), value-to-choice (magnocellular mediodorsal nucleus), mnemonic-to-choice (anteromedial nucleus) and sensory-to-choice (medial pulvinar). Common mechanisms appear to be thalamic modulation of cortical gain and cortico-cortical functional connectivity. The anatomy also implies a unique role for medial PFC in modulating processing in thalamocortical circuits involving other orbital and lateral PFC regions. We further discuss how cortico-basal ganglia circuits may provide a mechanism through which PFC controls cortico-cortical functional connectivity.
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影响因子：
2
作者：
Bachevalier, J;Meunier, M;Ungerleider, LG
通讯作者：
Ungerleider, LG
影响因子：
2.6
作者：
AGGLETON, JP;MISHKIN, M
通讯作者：
MISHKIN, M
影响因子：
2.5
作者：
AGGLETON, JP;MISHKIN, M
通讯作者：
MISHKIN, M
影响因子：
3.5
作者：
Baddeley, AD
通讯作者：
Baddeley, AD
影响因子：
2.4
作者：
Barbas H;Saha S;Rempel-Clower N;Ghashghaei T
通讯作者：
Ghashghaei T