Complex effects of NMDA receptor antagonist APV in the basolateral amygdala on acquisition of two-way avoidance reaction and long-term fear memory.
Complex effects of NMDA receptor antagonist APV in the basolateral amygdala on acquisition of two-way avoidance reaction and long-term fear memory.
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NMDA 受体拮抗剂 APV 在基底外侧杏仁核对双向回避反应和长期恐惧记忆获得的复杂影响。
DOI：
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
L. Kaczmarek
中科院分区：
文献类型：
--
作者：
A. Savonenko;T. Werka;E. Nikolaev;K. Zieliński;L. Kaczmarek
尽管人们对杏仁核在巴甫洛夫恐惧条件反射中的作用已经了解得很多，但对该结构参与更复杂的厌恶学习（例如主动回避反应的获得）的了解相对较少。在本研究中，N-甲基-D-天冬氨酸（NMDA）受体拮抗剂，2-氨基-5-膦酰基戊酸（APV），在训练前注射到大鼠的基底外侧杏仁核（BLA）的双向主动回避学习被削弱。在穿梭箱中的多次试验训练期间，注射APV的大鼠在对电击的敏感性或对上下文线索的冻结的获取方面与对照组没有差异。然而，APV注射导致受损的保留上下文的恐惧时，测试48小时后，沿着衰减的c-Fos在杏仁核的表达。这些结果是一致的BLA的NMDA受体在长期记忆中的恐惧，以前记录在巴甫洛夫条件反射范式的作用。APV诱导的主动回避学习障碍与逃避反应的方向性和对条件刺激的注意力缺陷相一致。这些数据表明，正常运作的NMDA受体在基底外侧杏仁核是必需的，在收购适应性仪器反应穿梭箱，但在这种情况下，收购短期的上下文恐惧是没有必要的。
Although much has been learned about the role of the amygdala in Pavlovian fear conditioning, relatively little is known about an involvement of this structure in more complex aversive learning, such as acquisition of an active avoidance reaction. In the present study, rats with a pretraining injection of the N-methyl-D-aspartate (NMDA) receptor antagonist, 2-amino-5-phosphonopentanoic acid (APV), into the basolateral amygdala (BLA) were found to be impaired in two-way active avoidance learning. During multitrial training in a shuttle box, the APV-injected rats were not different from the controls in sensitivity to shock or in acquisition of freezing to contextual cues. However, APV injection led to impaired retention of contextual fear when tested 48 h later, along with an attenuation of c-Fos expression in the amygdala. These results are consistent with the role of NMDA receptors of the BLA in long-term memory of fear, previously documented in Pavlovian conditioning paradigms. The APV-induced impairment in the active avoidance learning coincided with deficits in directionality of the escape reaction and in attention to conditioned stimuli. These data indicate that normal functioning of NMDA receptors in the basolateral amygdala is required during acquisition of adaptive instrumental responses in a shuttle box but is not necessary for acquisition of short-term contextual fear in this situation.
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影响因子：
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影响因子：
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