Failure to use corollary discharge to remap visual target locations is associated with psychotic symptom severity in schizophrenia.
Failure to use corollary discharge to remap visual target locations is associated with psychotic symptom severity in schizophrenia.
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未能使用推论放电重新映射视觉目标位置与精神分裂症的精神病症状严重程度相关
DOI：
10.1152/jn.00155.2015
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发表时间：
2015
影响因子：
2.5
通讯作者：
Thakkar
中科院分区：
文献类型：
--
作者：
Rösler;van der Stigchel;Neggers;Thakkar
推论放电（CD）是指发送到感觉区域的运动信号的“副本”，可以预测未来的感觉状态。它们使假定的机制支持自我产生的感觉和外部产生的感觉之间的区别。因此，许多作者认为，受干扰的CD产生精神分裂症的精神病性症状，其特征是代理扭曲。CD还支持在扫视眼球运动中感知的视觉稳定性，并用于预测视觉刺激的扫视后视网膜坐标，这一过程称为重新映射。我们测试了精神分裂症患者（SZP）是否表现出视觉目标系统性跨扫视错位所证明的重映射障碍。SZP和健康对照组（HC）进行了一项任务，其中扫视目标消失后扫视启动，并在短暂的延迟后，出现在一个水平位移的位置。尽管眼跳着陆点存在空间误差，HC仍准确地判断了这种位移的方向，这表明他们对实际眼跳后目标位置与预测目标位置的比较依赖于准确的CD。SZP表现更差，更依赖于扫视着陆点作为扫视前目标的代理，与受干扰的CD一致。这种重新映射失败在更严重的精神病症状患者中最强，这与精神分裂症中CD紊乱和现象学经历之间的理论联系一致。
Corollary discharge (CD) refers to “copies” of motor signals sent to sensory areas, allowing prediction of future sensory states. They enable the putative mechanisms supporting the distinction between self-generated and externally generated sensations. Accordingly, many authors have suggested that disturbed CD engenders psychotic symptoms of schizophrenia, which are characterized by agency distortions. CD also supports perceived visual stability across saccadic eye movements and is used to predict the postsaccadic retinal coordinates of visual stimuli, a process called remapping. We tested whether schizophrenia patients (SZP) show remapping disturbances as evidenced by systematic transsaccadic mislocalizations of visual targets. SZP and healthy controls (HC) performed a task in which a saccadic target disappeared upon saccade initiation and, after a brief delay, reappeared at a horizontally displaced position. HC judged the direction of this displacement accurately, despite spatial errors in saccade landing site, indicating that their comparison of the actual to predicted postsaccadic target location relied on accurate CD. SZP performed worse and relied more on saccade landing site as a proxy for the presaccadic target, consistent with disturbed CD. This remapping failure was strongest in patients with more severe psychotic symptoms, consistent with the theoretical link between disturbed CD and phenomenological experiences in schizophrenia.
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精神分裂症患者视觉空间的周知知觉
DOI：
10.1523/jneurosci.4744-13.2014
发表时间：
2014
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
Alby Richard;J. Churan;Veronica Whitford;G. O’Driscoll;D. Titone;Christopher C. Pack
通讯作者：
Christopher C. Pack
DOI：
10.1176/appi.ajp.2012.12010056
发表时间：
2012-10
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Woodward ND;Karbasforoushan H;Heckers S
通讯作者：
Heckers S
影响因子：
4.3
作者：
Philippa Garety
通讯作者：
Philippa Garety
影响因子：
--
作者：
Kahn, Rene S.;Linszen, Don H.;Myin-Germeys, Inez
通讯作者：
Myin-Germeys, Inez
影响因子：
4.5
作者：
Leucht, S;Kane, JM;Engel, RR
通讯作者：
Engel, RR