Common Marmosets: A Potential Translational Animal Model of Juvenile Depression.
Common Marmosets: A Potential Translational Animal Model of Juvenile Depression.
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DOI：
10.3389/fpsyt.2017.00175
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发表时间：
2017
影响因子：
4.7
通讯作者：
de Sousa MBC
中科院分区：
文献类型：
--
作者：
Galvão-Coelho NL;Galvão ACM;da Silva FS;de Sousa MBC
抑郁症是一种在普通人群中发病率较高的精神障碍，在青春期有增加的表现，在年轻人中约占14%。通常，它表现为一种慢性疾病，即使在几次药物治疗后也没有缓解，并持续到成年。因此，已经开发了不同的方案和动物模型来增加对这种疾病的了解或寻找新的治疗方法。为此，本研究通过监测粪便皮质醇、体重和行为参数，寻找生物标志物和诱导抑郁的方案，研究了慢性社会隔离的影响和去甲替林对雌性和雄性Callithrix Jacchus幼体的潜在抗抑郁作用。目的是验证这个物种和方案作为青少年抑郁症的翻译模型，解决验证的所有领域标准：病因学、面孔、功能、预测性、相互关系、进化和人群。在男女患者中，在社交隔离的最后阶段，我们观察到皮质醇水平显著降低，伴随着自我美容、刻板印象和焦虑行为的增加，以及快感缺失的存在。慢性社会隔离引起的改变是非人灵长类和/或人类抑郁状态的特征，并在很大程度上被抗抑郁药物(去甲替林)逆转。因此，这些结果表明，通过解决所有的验证标准，雅克夏鱼是一种潜在的青少年抑郁症的翻译模型。
Major depression is a psychiatric disorder with high prevalence in the general population, with increasing expression in adolescence, about 14% in young people. Frequently, it presents as a chronic condition, showing no remission even after several pharmacological treatments and persisting in adult life. Therefore, distinct protocols and animal models have been developed to increase the understanding of this disease or search for new therapies. To this end, this study investigated the effects of chronic social isolation and the potential antidepressant action of nortriptyline in juvenile Callithrix jacchus males and females by monitoring fecal cortisol, body weight, and behavioral parameters and searching for biomarkers and a protocol for inducing depression. The purpose was to validate this species and protocol as a translational model of juvenile depression, addressing all domain criteria of validation: etiologic, face, functional, predictive, inter-relational, evolutionary, and population. In both sexes and both protocols (IDS and DPT), we observed a significant reduction in cortisol levels in the last phase of social isolation, concomitant with increases in autogrooming, stereotyped and anxiety behaviors, and the presence of anhedonia. The alterations induced by chronic social isolation are characteristic of the depressive state in non-human primates and/or in humans, and were reversed in large part by treatment with an antidepressant drug (nortriptyline). Therefore, these results indicate C. jacchus as a potential translational model of juvenile depression by addressing all criteria of validation.
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DOI：
10.1186/2045-5380-1-9
发表时间：
2011-11-07
期刊：
Biology of mood & anxiety disorders
影响因子：
--
作者：
Belzung C;Lemoine M
通讯作者：
Lemoine M
影响因子：
2.9
作者：
Adam, Tanja C.;Epel, Elissa S.
通讯作者：
Epel, Elissa S.
影响因子：
2.5
作者：
Beery, Annaliese K.;Lacey, Eileen A.;Francis, Darlene D.
通讯作者：
Francis, Darlene D.
影响因子：
24.8
作者：
Cacioppo JT;Cacioppo S;Capitanio JP;Cole SW
通讯作者：
Cole SW
影响因子：
4.3
作者：
Cinini SM;Barnabe GF;Galvão-Coelho N;de Medeiros MA;Perez-Mendes P;Sousa MB;Covolan L;Mello LE
通讯作者：
Mello LE