Reduced 25(OH) Vitamin D Association with Lower Alpha-1-Antitrypsin Blood Levels in Type 2 Diabetic Patients.
Reduced 25(OH) Vitamin D Association with Lower Alpha-1-Antitrypsin Blood Levels in Type 2 Diabetic Patients.
复制标题
2型糖尿病患者中25（OH）维生素D减少与较低的α-1-抗胰蛋白酶血液水平相关。
DOI：
10.1080/07315724.2020.1740629
复制
发表时间：
2021-03
影响因子：
3.5
通讯作者：
Jain SK
中科院分区：
文献类型：
--
作者：
Lindley VM;Bhusal K;Huning L;Levine SN;Jain SK
循环中25(OH)VD水平的降低与慢性肺部疾病的发病率增加有关。α-1-抗胰蛋白酶(AAT)是维持健康肺功能所必需的。这项研究验证了成人2型糖尿病患者循环AAT水平较低的假设，以及这些患者循环AAT水平与25(OH)VD水平之间存在正相关。根据人体研究机构审查委员会批准的方案，在LSUHSC诊所就诊的2型糖尿病患者(n=80)和正常兄弟姐妹或志愿者(n=22)的书面知情同意后获取空腹血液。用双抗体夹心法测定血浆AAT和25(OH)VD水平。在LSUHSC医院的临床实验室分析HbA1c水平和生化特征。与年龄匹配的健康对照组相比，2型糖尿病患者的ATT和25(OH)VD水平显著降低。25(OH)VD与ATT缺乏症呈显著正相关。2型糖尿病患者AAT水平与高密度脂蛋白胆固醇水平呈显著正相关。T2D患者AAT水平与HbA1c及糖尿病病程均无相关性。这些结果提示，25(OH)VD缺乏可能使2型糖尿病患者易患AAT缺乏。循环AAT水平降低是否确实增加了2型糖尿病患者肺功能障碍的风险，还需要进一步研究。
Reduced circulating levels of 25(OH)VD are associated with an increased incidence of chronic lung diseases. Alpha-1-antitrypsin (AAT) is needed to maintain healthy lung function. This study examined the hypothesis that circulating levels of AAT are lower in adult type 2 diabetic patients and that a positive association exists between circulating AAT levels and 25(OH)VD levels in these patients. Fasting blood was obtained after written informed consent from type 2 diabetic patients (n=80) and normal siblings or volunteers (n=22) attending clinics at LSUHSC according to the protocol approved by the Institutional Review Board for Human studies. Plasma AAT and 25(OH)VD levels were determined using ELISA kits. HbA1c levels and chemistry profiles were analyzed at the clinical laboratory of LSUHSC hospital. ATT and 25(OH)VD levels were significantly lower in type 2 diabetic patients compared with those of age-matched healthy controls. There was a significant positive correlation between 25(OH)VD and ATT deficiency. AAT levels showed significant positive correlation with HDL cholesterol levels in type 2 diabetic patients. There was no correlation between AAT levels and those of HbA1c or with the duration of diabetes of T2D patients. These results suggest that 25(OH)VD deficiency may predispose type 2 diabetic patients to AAT deficiency. Whether reduced levels of circulating AAT indeed contribute to the increased risk for lung dysfunction in subjects with type 2 diabetes needs further investigation.
登录
查看更多内容
影响因子：
4.2
作者：
Kim, Samuel M.;Zhao, Di;Michos, Erin D.
通讯作者：
Michos, Erin D.
影响因子：
3.8
作者：
Lisowska-Myjak, B.;Pachecka, J.;Kadziela, K.
通讯作者：
Kadziela, K.
DOI：
10.1080/07315724.2018.1538828
发表时间：
2019-07-04
影响因子：
3.5
作者：
Pantovic, Ana;Zec, Manja;Glibetic, Maria
通讯作者：
Glibetic, Maria
影响因子：
3.2
作者：
Putcha N;Drummond MB;Wise RA;Hansel NN
通讯作者：
Hansel NN
影响因子：
24.3
作者：
Greulich, Timm;Nell, Christoph;Vogelmeier, Claus Franz
通讯作者：
Vogelmeier, Claus Franz