Allelic imbalances of chromosomes 8p and 18q and their roles in distant relapse of early stage, node-negative breast cancer.
Allelic imbalances of chromosomes 8p and 18q and their roles in distant relapse of early stage, node-negative breast cancer.
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DOI：
10.1186/bcr1349
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发表时间：
2005
影响因子：
7.4
通讯作者：
Zhou, W
中科院分区：
文献类型：
--
作者：
Morikawa, A;Williams, TY;Dirix, L;Colpaert, C;Goodman, M;Lyles, RH;Zhong, DS;Zhou, W
乳腺癌术后远处复发风险的鉴别是一个重要的临床问题。现有病理标志物仅能在一定程度上预测疾病复发，还需要更准确的预测指标。采用“计数等位基因”这一新颖的实验方法，我们在65例早期淋巴结阴性浸润性导管癌（IDCs）的病例对照研究中测定了染色体8p和18q的等位基因状态。研究了染色体标记的等位基因失衡（AI）与远处复发之间的关系。80%的肿瘤含有8pAI， 68%的肿瘤含有18qAI。然而，没有肿瘤样本同时保留染色体8p和18q等位基因。更重要的是，与含有18qAI而非8pAI的肿瘤相比，含有8pAI而非18qAI的肿瘤更容易远处复发。我们的发现表明，染色体8p和18q的差异等位基因丢失可能代表早期IDC的亚型，具有不同的肿瘤进展行为。
Identification of breast cancer patients at risk for postoperative distant relapse is an important clinical issue. Existing pathological markers can predict disease recurrence only to a certain extent, and there is a need for more accurate predictors. Using 'counting alleles', a novel experimental method, we determined allelic status of chromosomes 8p and 18q in a case-control study with 65 early stage, node negative, invasive ductal carcinomas (IDCs). The association between allelic imbalance (AI) of both chromosomal markers and distant relapses was examined. Eighty percent of tumors contained 8pAI and sixty-eight percent of tumors contained 18qAI. However, none of the tumor samples retained both chromosome 8p and 18q alleles. More importantly, tumors with 8pAI but not 18qAI were more likely to have distant relapse compared to tumors with 18qAI but not 8pAI. Our finding suggests that differential allelic loss of chromosomes 8p and 18q may represent subtypes of early stage IDC with different tumor progression behaviors.
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