South African Children: A Matched Cohort Study of Neurodevelopmental Impairment in Survivors of Invasive Group B Streptococcus Disease Aged 5 to 8 Years.
South African Children: A Matched Cohort Study of Neurodevelopmental Impairment in Survivors of Invasive Group B Streptococcus Disease Aged 5 to 8 Years.
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DOI：
10.1093/cid/ciab814
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发表时间：
2022-01-20
期刊：
影响因子：
--
通讯作者：
Dangor Z
中科院分区：
文献类型：
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作者：
Harden LM;Leahy S;Lala SG;Paul P;Chandna J;Lowick S;Mbatha S;Jaye T;Laughton B;Ghoor A;Sithole P;Msayi J;Kumalo N;Msibi TN;Madhi SA;Lawn JE;Dangor Z
侵袭性B族链球菌（iGBS）败血症和脑膜炎是儿童死亡的重要原因，但对iGBS后神经发育障碍（NDI）的研究有限。使用格里菲斯心理发展量表-扩展修订版（GMDS-ER），我们描述了来自南非的iGBS幸存者和非iGBS儿童的NDI，作为五国研究的一部分。我们确定了2019年10月至2021年1月期间有iGBS病史的5-8岁儿童和无iGBS病史的儿童。儿童的性别和出生数据（月份、年份）相匹配（匹配队列研究）。中度或重度NDI是GMDS-ER运动、GMDS-ER认知、听力和视力综合的主要结局。次要结局包括轻度NDI、任何情绪-行为问题和GMDS-ER发育商（DQ），计算方法是将GMDS-ER的年龄当量分数除以实足年龄。总共评估了160名儿童（iGBS幸存者43名，非iGBS患者117名）。在iGBS幸存者中，13人（30.2%）患有脑膜炎，30人（69.8%）患有败血症。6名（13.9%）iGBS幸存者和5名（4.3%）非iGBS儿童患有中度或重度NDI。iGBS存活儿童在5-8岁时发生中度或重度NDI的可能性是非iGBS儿童的5.56倍（95%可信区间[CI]: 1.07-28.93; P = 0.041）。与非iGBS儿童相比，iGBS脑膜炎幸存者的总体中位DQ显著降低（P < 0.05）。语言GMDS-ER子量表和表现GMDS-ER子量表的DQ中位数较低（P < 0.05）。与非iGBS儿童相比，存活于iGBS（尤其是脑膜炎）的儿童更有可能在5-8岁时发生NDI。需要进一步研究以改进对高危新生儿的检测和护理。
Invasive group B Streptococcus (iGBS) sepsis and meningitis are important causes of child mortality, but studies on neurodevelopmental impairment (NDI) after iGBS are limited. Using Griffiths Mental Development Scales–Extended Revised (GMDS-ER), we described NDI in iGBS survivors and non-iGBS children from South Africa, as part of a 5-country study. We identified children aged 5–8 years with a history of iGBS and children with no history of iGBS between October 2019 and January 2021. Children were matched on sex, and birth data (month, year) (matched cohort study). Moderate or Severe NDI was the primary outcome as a composite of GMDS-ER motor, GMDS-ER cognition, hearing, and vision. Secondary outcomes included mild NDI, any emotional-behavioral problems, and GMDS-ER developmental quotients (DQ) calculated by dividing the age equivalent GMDS-ER score by the chronological age. In total, 160 children (iGBS survivors, 43; non-iGBS, 117) were assessed. Among iGBS survivors 13 (30.2%) had meningitis, and 30 (69.8%) had sepsis. Six (13.9%) iGBS survivors, and 5 (4.3%) non-iGBS children had moderate or severe NDI. Children who survived iGBS were 5.56 (95% confidence interval [CI]: 1.07–28.93; P = .041) times more likely to have moderate or severe NDI at 5–8 years than non-iGBS children. Compared to the non-iGBS children, iGBS meningitis survivors had a significantly lower global median DQ (P < .05), as well as a lower median DQ for the language GMDS-ER subscale and performance GMDS-ER subscale (P < .05). Children surviving iGBS, particularly meningitis, are more likely to have NDI at 5–8 years compared to non-iGBS children. Further research is required to improve detection and care for at-risk newborns.
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影响因子：
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作者：
Paul, Proma;Procter, Simon R;Lawn, Joy E
通讯作者：
Lawn, Joy E
DOI：
10.1093/cid/cix656
发表时间：
2017-11-06
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
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通讯作者：
Infant GBS Disease Investigator Group
影响因子：
3.7
作者：
Dangor, Ziyaad;Lala, Sanjay G.;Madhi, Shabir A.
通讯作者：
Madhi, Shabir A.
影响因子：
36.4
作者：
Wedderburn, Catherine;Yeung, Shunmay;Donald, Kirsten A.
通讯作者：
Donald, Kirsten A.
DOI：
10.1093/cid/ciab792
发表时间：
2022-01-20
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
John HB;Arumugam A;Priya M;Murugesan N;Rajendraprasad N;Rebekah G;Paul P;Chandna J;Lawn JE;Santhanam S
通讯作者：
Santhanam S