Toxicity Assessment of Mesoporous Silica Nanoparticles upon Intravenous Injection in Mice: Implications for Drug Delivery.
Toxicity Assessment of Mesoporous Silica Nanoparticles upon Intravenous Injection in Mice: Implications for Drug Delivery.
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DOI：
10.3390/pharmaceutics14050969
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发表时间：
2022-04-30
期刊：
影响因子：
5.4
通讯作者：
McNally, Lacey R.
中科院分区：
文献类型：
--
作者：
MacCuaig, William M.;Samykutty, Abhilash;Foote, Jeremy;Luo, Wenyi;Filatenkov, Alexander;Li, Min;Houchen, Courtney;Grizzle, William E.;McNally, Lacey R.
纳米颗粒是用于选择性递送药物和造影剂以识别和治疗疾病的流行工具。为了确定介孔二氧化硅纳米颗粒（MSN）的有用性和转化潜力，需要进一步评估毒性。MSN是最常用的纳米递送系统之一，因为其易于合成、孔结构和功能化。本研究旨在阐明小鼠静脉注射涂有壳聚糖（C）或聚乙二醇（PEG）的25 nm MSN所产生的毒性。在急性和慢性注射后，评价血液用于标准血液化学和全血细胞计数分析。血液化学结果主要表明，在急性或慢性注射MSN或C/PEG包被的MSN后，不存在异常。每周给药4次后，重要器官显示35 KPEG-MSN组中既存病变轻微加重，无涂层MSN和2KPEG-MSN治疗组中既存病变中度加重。相比之下，C-MSN治疗组与对照组相比变化最小。该研究表明，当单次或多次静脉注射给药时，用壳聚糖涂覆的25 nm MSN应引起最小的毒性，但用PEG涂覆的MSN，特别是2KPEG，可能会加剧预先存在的血管疾病。进一步的研究应该评估不同尺寸和类型的纳米颗粒，以提供更好的整体理解纳米颗粒和体内毒性之间的关系。
Nanoparticles are popular tools utilized to selectively deliver drugs and contrast agents for identification and treatment of disease. To determine the usefulness and translational potential of mesoporous silica nanoparticles (MSNs), further evaluations of toxicity are required. MSNs are among the most utilized nano-delivery systems due to ease of synthesis, pore structure, and functionalization. This study aims to elucidate toxicity as a result of intravenous injection of 25 nm MSNs coated with chitosan (C) or polyethylene glycol (PEG) in mice. Following acute and chronic injections, blood was evaluated for standard blood chemistry and complete blood count analyses. Blood chemistry results primarily indicated that no abnormalities were present following acute or chronic injections of MSNs, or C/PEG-coated MSNs. After four weekly administered treatments, vital organs showed minor exacerbation of pre-existing lesions in the 35KPEG-MSN and moderate exacerbation of pre-existing lesions in uncoated MSN and 2KPEG-MSN treatment groups. In contrast, C-MSN treatment groups had minimal changes compared to controls. This study suggests 25 nm MSNs coated with chitosan should elicit minimal toxicity when administered as either single or multiple intravenous injections, but MSNs coated with PEG, especially 2KPEG may exacerbate pre-existing vascular conditions. Further studies should evaluate varying sizes and types of nanoparticles to provide a better overall understanding on the relation between nanoparticles and in vivo toxicity.
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影响因子：
5.8
作者：
Andreani, Tatiana;de Souza, Ana Luiza R.;Souto, Eliana B.
通讯作者：
Souto, Eliana B.
表面修饰二氧化硅纳米粒子的生物分布和尿液排泄的体内研究
影响因子：
7.4
作者：
He, Xiaoxiao;Nie, Hailong;Zhang, Pengfei
通讯作者：
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影响因子：
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作者：
BABCOCK, MB;CARDELL, RR
通讯作者：
CARDELL, RR
影响因子：
5.4
作者：
Frickenstein AN;Hagood JM;Britten CN;Abbott BS;McNally MW;Vopat CA;Patterson EG;MacCuaig WM;Jain A;Walters KB;McNally LR
通讯作者：
McNally LR
影响因子：
5.2
作者：
Bhaysar, Dhaval;Patel, Vijay;Sawant, Krutika
通讯作者：
Sawant, Krutika