Bone repair scaffold coated with bone morphogenetic protein-2 for bone regeneration in murine calvarial defect model: Systematic review and quality evaluation
Bone repair scaffold coated with bone morphogenetic protein-2 for bone regeneration in murine calvarial defect model: Systematic review and quality evaluation
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涂有骨形态发生蛋白-2的骨修复支架用于小鼠颅骨缺损模型骨再生：系统评价和质量评价
DOI：
10.1177/0391398819834944
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发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
张涛
中科院分区：
文献类型：
--
作者：
曾建华;邱鹏;熊龙;刘世伟;丁凌华;熊世浪;李经堂;肖泽埠;张涛
系统评估骨形态发生蛋白-2.涂层羟基磷灰石骨修复支架对小鼠颅骨缺损模型的影响，并根据Animal Research Reporting.in In Vivo Experiments指南确定研究质量。使用PubMed、MEDLINE、奥维德和.Embase数据库进行了一式两份的互联网检索（不限制出版日期）。体内实验动物研究报告指南用于评价所选研究的质量。筛选后，12项研究符合审查条件。质量系数一般的文献占66.67%，质量系数差的文献占25%，质量系数优的文献占8.33%。最低质量评分分配给体内实验动物研究报告指南项目：圈养和饲养（9）、分配（11）、结局（12）、解释（18）和可推广性（19）。Sprague-Dawley大鼠是最常用的种属（50%），大多数研究的样本量超过30只。（58.33%）。5 mm的缺损最常见（33.33%）。生物羟基磷灰石复合支架最常见（50%），生物活性因子为骨形态发生蛋白-2（50%）和重组人骨形态发生蛋白-2（50%）。骨形态计量学结果表明，骨形态发生蛋白-2能显著增强骨再生能力。此外，支架与骨形态发生蛋白-2导致。在新骨血管显着增加。结果表明，骨形态发生蛋白-2涂层羟基磷灰石支架在小鼠颅骨缺损模型中的动物实验数据缺乏均一性。动物实验应遵循《动物研究报告在体实验指南》，以促进高质量、完整性和可重复性。本系统综述表明骨形态发生蛋白-2可增强骨再生能力和新骨中的血管生成
To systematically assess the effects of hydroxyapatite bone repair scaffold coated with bone morphogenetic protein-2.on murine calvarial defect models and to determine the quality of studies according to the Animal Research Reporting.in In Vivo Experiments guidelines. Internet search was performed in duplicate using PubMed, MEDLINE, Ovid and.Embase databases (without restrictions on publication date). The Animal Research Reporting in In Vivo Experiments.guidelines were used to evaluate the quality of selected studies. Following screening, 12 studies were eligible for the.review. Studies with average quality coefficients predominated (66.67%), followed by poor (25%) and excellent (8.33%).quality coefficients. Minimum quality scores were assigned to the Animal Research Reporting in In Vivo Experiments.guideline items: housing and husbandry (9), allocation (11), outcomes (12), interpretation (18) and generalizability (19)..Sprague–Dawley rats were the most frequently used (50%) species, and most studies had a sample size of more than 30.(58.33%). A defect dimension of 5mm was the most common (33.33%). The biological hydroxyapatite composite scaffold.was common (50%), and the bioactive factors were bone morphogenetic protein-2 (50%) and recombinant human bone.morphogenetic protein-2 (50%). Histomorphometric results showed that bone morphogenetic protein-2 enhanced.the capacity to regenerate bone considerably. In addition, scaffolds with bone morphogenetic protein-2 resulted in.a significant increase in the blood vessel in the new bone. The findings suggested that data on animal experiments of.hydroxyapatite scaffold coated with bone morphogenetic protein-2 in murine calvarial defect models lack homogeneity..Animal experiment should follow the Animal Research Reporting in In Vivo Experiments guidelines to promote the high.quality, integrity and reproducibility. This systematic review suggested that bone morphogenetic protein-2 enhanced the.capacity to regenerate bone and the angiogenesis in the new bone
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影响因子：
4
作者：
Sungyeun Yang;T. Hwang;Lihua Che;J. Oh;Yoon Ha;W. Ryu
通讯作者：
Sungyeun Yang;T. Hwang;Lihua Che;J. Oh;Yoon Ha;W. Ryu
通过加载 BMP-2 释放壳聚糖/藻酸盐/羟基磷灰石支架上的 MSC 来增强大鼠颅骨缺损的愈合。
影响因子：
3.7
作者：
He X;Liu Y;Yuan X;Lu L
通讯作者：
Lu L
中空羟基磷灰石微球：一种新型生物活性和骨传导载体，用于骨再生中骨形态发生蛋白2的控制释放。
影响因子：
9.7
作者：
Xiao, Wei;Fu, Hailuo;Rahaman, Mohamed N.;Liu, Yonxing;Bal, B. Sonny
通讯作者：
Bal, B. Sonny
DOI：
10.3390/ma10010033
发表时间：
2017-01-03
期刊：
Materials (Basel, Switzerland)
影响因子：
--
作者：
Tanaka M;Haniu H;Kamanaka T;Takizawa T;Sobajima A;Yoshida K;Aoki K;Okamoto M;Kato H;Saito N
通讯作者：
Saito N
影响因子：
0.9
作者：
Abdelaal, MM;Tholpady, SS;Ogle, RC
通讯作者：
Ogle, RC