Longitudinal Structural MRI Findings in Individuals at Genetic and Clinical High Risk for Psychosis: A Systematic Review.
Longitudinal Structural MRI Findings in Individuals at Genetic and Clinical High Risk for Psychosis: A Systematic Review.
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精神病遗传和临床高风险个体的纵向结构 MRI 结果：系统评价。
DOI：
10.3389/fpsyt.2021.620401
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发表时间：
2021
影响因子：
4.7
通讯作者：
David AS
中科院分区：
文献类型：
--
作者：
Merritt K;Luque Laguna P;Irfan A;David AS
背景：几项横断面研究报告了健康志愿者和遗传或临床高危精神分裂症患者的大脑结构差异。然而，纵向研究对于确定大脑发育轨迹的改变是否在精神病发病之前是重要的。方法：我们进行了一项系统的回顾，以确定(I)与健康志愿者相比，那些有精神病史(PE)、遗传病(GHR)或临床高危(CHR)的人，以及(Ii)那些过渡到精神病的人与那些没有精神病史的人，大脑轨迹是否不同。结果：在2473名高危受试者和990名健康志愿者中，38项研究测量了灰质，18项研究测量了白质。GHR、CHR和PE受试者表现出灰质的加速下降，主要是在颞叶，也包括额叶、扣带回和顶叶皮质。在那些仍然有症状或过渡到精神错乱的人中，灰质丢失在这些大脑区域更加明显。白质体积和各向异性分数通常增加到成年早期，但在高危受试者的扣带、丘脑辐射、小脑、内囊豆状后部分和海马丘脑束中没有改变或减少。在那些转变的人中，额枕束下部和上部的白质体积和各向异性分数随着时间的推移而减少，穹隆体部、内囊前肢、上冠放射状和距骨皮质的白质体积和各向异性分数随时间减少。结论：高危受试者表现出白质成熟缺陷和灰质加速衰退。灰质丢失在那些过渡到精神错乱的人中更加明显，但在汇款者中可能在成年早期恢复正常。
Background: Several cross-sectional studies report brain structure differences between healthy volunteers and subjects at genetic or clinical high risk of developing schizophrenia. However, longitudinal studies are important to determine whether altered trajectories of brain development precede psychosis onset. Methods: We conducted a systematic review to determine if brain trajectories differ between (i) those with psychotic experiences (PE), genetic (GHR) or clinical high risk (CHR), compared to healthy volunteers, and (ii) those who transition to psychosis compared to those who do not. Results: Thirty-eight studies measured gray matter and 18 studies measured white matter in 2,473 high risk subjects and 990 healthy volunteers. GHR, CHR, and PE subjects show an accelerated decline in gray matter primarily in temporal, and also frontal, cingulate and parietal cortex. In those who remain symptomatic or transition to psychosis, gray matter loss is more pronounced in these brain regions. White matter volume and fractional anisotropy, which typically increase until early adulthood, did not change or reduced in high risk subjects in the cingulum, thalamic radiation, cerebellum, retrolenticular part of internal capsule, and hippocampal–thalamic tracts. In those who transitioned, white matter volume and fractional anisotropy reduced over time in the inferior and superior fronto-occipital fasciculus, corpus callosum, anterior limb of the internal capsule, superior corona radiate, and calcarine cortex. Conclusion: High risk subjects show deficits in white matter maturation and an accelerated decline in gray matter. Gray matter loss is more pronounced in those who transition to psychosis, but may normalize by early adulthood in remitters.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
--
作者：
Gogtay, Nitin;Hua, Xue;Stidd, Reva;Boyle, Christina P.;Lee, Suh;Weisinger, Brian;Chavez, Alex;Giedd, Jay N.;Clasen, Liv;Toga, Arthur W.;Rapoport, Judith L.;Thompson, Paul M.
通讯作者：
Thompson, Paul M.
影响因子：
4.5
作者：
Bois, C.;Levita, L.;Lawrie, S. M.
通讯作者：
Lawrie, S. M.
心脏病的前驱青年有联系的心室增大和逐步减少皮质灰质。
影响因子：
4.5
作者：
Chung Y;Haut KM;He G;van Erp TGM;McEwen S;Addington J;Bearden CE;Cadenhead K;Cornblatt B;Mathalon DH;McGlashan T;Perkins D;Seidman LJ;Tsuang M;Walker E;Woods SW;Cannon TD;North American Prodrome Longitudinal Study (NAPLS) Consortium
通讯作者：
North American Prodrome Longitudinal Study (NAPLS) Consortium
影响因子：
5.7
作者：
Alloza C;Cox SR;Blesa Cábez M;Redmond P;Whalley HC;Ritchie SJ;Muñoz Maniega S;Valdés Hernández MDC;Tucker-Drob EM;Lawrie SM;Wardlaw JM;Deary IJ;Bastin ME
通讯作者：
Bastin ME