The prevalence and isolated subtypes of BK polyomavirus reactivation among patients infected with human immunodeficiency virus-1 in southeastern China.
The prevalence and isolated subtypes of BK polyomavirus reactivation among patients infected with human immunodeficiency virus-1 in southeastern China.
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DOI：
10.1007/s00705-018-3724-y
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发表时间：
2018-06
影响因子：
2.7
通讯作者：
Zhu B
中科院分区：
文献类型：
--
作者：
Hu C;Huang Y;Su J;Wang M;Zhou Q;Zhu B
BK多瘤病毒（BK Polyomavirus，BKPyV）是一种机会性感染病原体，其与出血性膀胱炎和肾病相关，主要在移植受体和人类免疫缺陷病毒1（HIV-1）感染的患者中。然而，BKPyV在中国的分子特征研究很少。本研究旨在阐明中国东南部HIV-1感染者中BKPyV的流行情况并确定其主要亚型。此外，还分析了BKPyV再活化发生率的增加。用PCR方法扩增BKPyV基因，并与参考序列进行同源性分析。在这项研究中，在64.2%（88/137）的HIV-1感染者中检测到BKPyV病毒尿。BKPyV阳性组患者在性别（P = 0.039）和年龄（P = 0.023）方面比BKPyV阴性组患者更多样化，并且他们与结核病（TB）的合并感染率更高（P = 0.026）。CD 4 <200 cells/mm的患者病毒尿发生率（72.7%）高于CD 4 ≥200 cells/mm的患者（58.5%）（无显著性差异）。所有测序的BKPyV分离株均属于I型（13/32）和IV型（19/32）。在HIV-1感染患者中发现了BKPyV再激活的高患病率。在这项研究中，女性和老年人以及合并结核病感染的人似乎更容易受到BKPyV再激活的影响。BKPyV病毒尿更常见，并与较低的CD 4计数相关。
BK polyomavirus (BKPyV) is an opportunistic infectious pathogen that is associated with hemorrhagic cystitis and nephropathy, mainly in transplant recipients and human immunodeficiency virus 1 (HIV-1) infected patients. However, molecular characterization studies of BKPyV in China are rare. This study was designed to elucidate the prevalence and to determine the main subtypes of BKPyV among HIV-1-infected patients in southeastern China. In addition, the increased incidences for BKPyV reactivation were analyzed. The isolated BKPyV DNA was amplified by polymerase chain reaction (PCR) and the specimen sequences were aligned with the reference sequences for phylogenetic analysis. In this study, BKPyV viruria was detected in 64.2% (88/137) of HIV-1-infected patients. Patients in the BKPyV-positive group were more diverse with respect to gender (P = 0.039) and age (P = 0.023) than their counterparts in the BKPyV-negative group, and they had a higher rate of co-infection with tuberculosis (TB) (P = 0.026). Viruria was more commonly found in patients with CD4 counts <200 cells/mm (72.7%) than in those with CD4 counts ≥200 cells/mm (58.5%) (not significant). All sequenced BKPyV isolates belonged to subtype I (13/32) and IV (19/32). A high prevalence of BKPyV reactivation was discovered in patients with HIV-1 infection. Females and elderly individuals, as well as those with a TB co-infection, appeared more susceptible to BKPyV reactivation in this study. BKPyV viruria was found more often and was associated with lower CD4 counts.
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影响因子：
3.9
作者：
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通讯作者：
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DOI：
10.4103/1319-2442.139936
发表时间：
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作者：
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作者：
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通讯作者：
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DOI：
10.1590/s0074-02762011000800006
发表时间：
2011-12-01
期刊：
Memórias do Instituto Oswaldo Cruz
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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