Low frequency visual stimulation enhances slow wave activity without disrupting the sleep pattern in mice.
Low frequency visual stimulation enhances slow wave activity without disrupting the sleep pattern in mice.
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DOI：
10.1038/s41598-022-16478-8
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发表时间：
2022-07-19
影响因子：
4.6
通讯作者：
Gerashchenko, Dmitry
中科院分区：
文献类型：
--
作者：
Thankachan, Stephen;Yang, Chun;Kastanenka, Ksenia, V;Bacskai, Brian J.;Gerashchenko, Dmitry
非侵入性刺激技术正在成为一系列神经退行性疾病的潜在治疗选择。实验证据表明，刺激引起的大脑慢节奏变化可能减轻甚至预防神经病理和行为障碍。慢波活动在睡眠期间普遍存在，可以通过针对视觉系统的感觉刺激或直接通过使用光遗传学局部激活神经元而非侵入性地触发。在这里，我们开发了新的工具，使用发光二极管在清醒和睡眠时自由移动的小鼠中传递视觉刺激。我们将这些工具与用于局部刺激大脑皮层神经元的传统光遗传学方法进行了比较。然后，我们使用这些工具来比较低频视觉和光遗传刺激对小鼠慢波活动和睡眠模式的影响。视觉刺激在不扰乱睡眠模式的情况下有效地增强了慢波活动。光遗传刺激皮质gaba能神经元增加非快速眼动睡眠。这些结果表明，视觉刺激可以有效地促进慢波活动，而不会对睡眠产生不利影响，因此作为一种非侵入性刺激治疗策略具有很大的潜力。
Non-invasive stimulation technologies are emerging as potential treatment options for a range of neurodegenerative disorders. Experimental evidence suggests that stimuli-evoked changes in slow brain rhythms may mitigate or even prevent neuropathological and behavioral impairments. Slow wave activity is prevalent during sleep and can be triggered non-invasively by sensory stimulation targeting the visual system or directly via activation of neurons locally using optogenetics. Here, we developed new tools for delivering visual stimulation using light-emitting diodes in freely moving mice while awake and during sleep. We compared these tools to traditional optogenetic approaches used for local stimulation of neurons in the cerebral cortex. We then used these tools to compare the effects of low-frequency visual versus optogenetic stimulations on the slow wave activity and sleep pattern in mice. Visual stimulation effectively enhanced slow wave activity without disrupting the sleep pattern. Optogenetic stimulation of cortical GABAergic neurons increased NREM sleep. These results suggest that visual stimulation can be effective at boosting slow wave activity without having adverse effects on sleep and thus holds great potential as a non-invasive stimulation treatment strategy.
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DOI：
10.1073/pnas.1508080112
发表时间：
2015-11-03
影响因子：
11.1
作者：
Chen, Xiaogang;Wang, Yijun;Gao, Shangkai
通讯作者：
Gao, Shangkai
追踪小鼠睡眠期间的眼球运动
影响因子：
4.3
作者：
Meng Q;Tan X;Jiang C;Xiong Y;Yan B;Zhang J
通讯作者：
Zhang J
影响因子：
3.7
作者：
Gerber EM;Sadeh B;Ward A;Knight RT;Deouell LY
通讯作者：
Deouell LY
影响因子：
16.6
作者：
Knopfel, Thomas;Sweeney, Yann;Barnes, Samuel J.
通讯作者：
Barnes, Samuel J.
影响因子：
25
作者：
Krone LB;Yamagata T;Blanco-Duque C;Guillaumin MCC;Kahn MC;van der Vinne V;McKillop LE;Tam SKE;Peirson SN;Akerman CJ;Hoerder-Suabedissen A;Molnár Z;Vyazovskiy VV
通讯作者：
Vyazovskiy VV