Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020-06.
Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020-06.
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DOI：
10.1186/1471-2164-11-652
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发表时间：
2010-11-23
期刊：
影响因子：
4.4
通讯作者：
Maiden MC
中科院分区：
文献类型：
--
作者：
Bennett JS;Bentley SD;Vernikos GS;Quail MA;Cherevach I;White B;Parkhill J;Maiden MC
奈瑟菌属含有两种重要但又非常不同的病原体，即脑膜炎奈瑟菌和淋病奈瑟菌，此外还有非致病性奈瑟菌，其中内酰胺奈瑟菌的特征最好。这三种细菌的基因组比较将提供对这组生物发病机制和进化的见解，这适用于更广泛地理解这些过程。非致病性内酰胺奈瑟菌表现出与脑膜炎球菌非常相似的种群结构和多样性水平，而淋球菌基本上是单一克隆的近期后代。这三个物种共享一个共同的核心基因集，估计包含约1190个cds，相当于约60%的基因组。然而，这个核心基因组中的一些核苷酸序列多样性是每个群体特有的，这表明在这个共享的核心基因集中，跨物种重组是罕见的。除了编码多糖囊的脑膜炎球菌cps区域外，相对较少的大型附属基因库成员专属于一个物种群，并且该附属基因组内的跨物种重组是频繁的。这三个奈瑟菌种群代表了一致的生物学和遗传类群，似乎是通过核心基因组内低比率的种间水平遗传交换来维持的。有大量证据表明，正选择基因与辅助基因组之间存在交换，一些证据表明，管家基因与其他基因座之间存在搭便车现象。为这组生物体定义“致病基因组”是不可能的，因此引起疾病的表型可能是复杂的、多基因的，并且在观察到的各种疾病相关表型中是不同的。
The genus Neisseria contains two important yet very different pathogens, N. meningitidis and N. gonorrhoeae, in addition to non-pathogenic species, of which N. lactamica is the best characterized. Genomic comparisons of these three bacteria will provide insights into the mechanisms and evolution of pathogenesis in this group of organisms, which are applicable to understanding these processes more generally. Non-pathogenic N. lactamica exhibits very similar population structure and levels of diversity to the meningococcus, whilst gonococci are essentially recent descendents of a single clone. All three species share a common core gene set estimated to comprise around 1190 CDSs, corresponding to about 60% of the genome. However, some of the nucleotide sequence diversity within this core genome is particular to each group, indicating that cross-species recombination is rare in this shared core gene set. Other than the meningococcal cps region, which encodes the polysaccharide capsule, relatively few members of the large accessory gene pool are exclusive to one species group, and cross-species recombination within this accessory genome is frequent. The three Neisseria species groups represent coherent biological and genetic groupings which appear to be maintained by low rates of inter-species horizontal genetic exchange within the core genome. There is extensive evidence for exchange among positively selected genes and the accessory genome and some evidence of hitch-hiking of housekeeping genes with other loci. It is not possible to define a 'pathogenome' for this group of organisms and the disease causing phenotypes are therefore likely to be complex, polygenic, and different among the various disease-associated phenotypes observed.
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影响因子：
3.3
作者：
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通讯作者：
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影响因子：
3.1
作者：
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通讯作者：
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