Biomimetic Precapillary Flow Patterns for Enhancing Blood Plasma Separation: A Preliminary Study.

Biomimetic Precapillary Flow Patterns for Enhancing Blood Plasma Separation: A Preliminary Study.
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DOI:
10.3390/s16091543
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发表时间:
2016-09-21
期刊:
Sensors (Basel, Switzerland)
影响因子:
--
通讯作者:
Kim S
Kim S
中科院分区:
其他
文献类型:
--
作者:
Namgung B;Tan JK;Wong PA;Park SY;Leo HL;Kim S

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本文研究了一种仿生微流控等离子体分离装置。该装置的设计灵感来自于对血管分叉下游增强的无细胞层(CFL)形成的体内观察。等离子体分离的工作原理是基于小动脉分叉中的等离子体掠过效应,该效应由CFL形成调节。CFL宽度的增强是通过在收集通道附近产生不均匀的红细胞压积分布来减少局部红细胞压积来实现的。该装置在红细胞比容(~40%)的生理水平上具有高纯度(~99.9%)。
In this study, a biomimetic microfluidic plasma separation device is discussed. The design of the device drew inspiration from in vivo observations of enhanced cell-free layer (CFL) formation downstream of vascular bifurcations. The working principle for the plasma separation was based on the plasma skimming effect in an arteriolar bifurcation, which is modulated by CFL formation. The enhancement of the CFL width was achieved by a local hematocrit reduction near the collection channel by creating an uneven hematocrit distribution at the bifurcation of the channel. The device demonstrated a high purity of separation (~99.9%) at physiological levels of hematocrit (~40%).
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