Biomimetic Precapillary Flow Patterns for Enhancing Blood Plasma Separation: A Preliminary Study.
Biomimetic Precapillary Flow Patterns for Enhancing Blood Plasma Separation: A Preliminary Study.
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DOI:
10.3390/s16091543
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发表时间:
2016-09-21
期刊:
影响因子:
--
通讯作者:
Kim S
中科院分区:
文献类型:
--
作者:
Namgung B;Tan JK;Wong PA;Park SY;Leo HL;Kim S
In this study, a biomimetic microfluidic plasma separation device is discussed. The design of the device drew inspiration from in vivo observations of enhanced cell-free layer (CFL) formation downstream of vascular bifurcations. The working principle for the plasma separation was based on the plasma skimming effect in an arteriolar bifurcation, which is modulated by CFL formation. The enhancement of the CFL width was achieved by a local hematocrit reduction near the collection channel by creating an uneven hematocrit distribution at the bifurcation of the channel. The device demonstrated a high purity of separation (~99.9%) at physiological levels of hematocrit (~40%).
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