The Role of the Adipokines in the Most Common Gestational Complications.
The Role of the Adipokines in the Most Common Gestational Complications.
复制标题
脂肪因子在最常见的妊娠并发症中的作用。
DOI：
10.3390/ijms21249408
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发表时间：
2020-12-10
影响因子：
5.6
通讯作者：
Wender-Ozegowska E
中科院分区：
文献类型：
--
作者：
Gutaj P;Sibiak R;Jankowski M;Awdi K;Bryl R;Mozdziak P;Kempisty B;Wender-Ozegowska E
脂肪细胞因子是一种重要的细胞活性分子，被认为在调节人体重要的生物学过程中起着关键作用。大量的实验研究证实了整个妊娠期间脂肪因子分泌模式的显著改变。各种妊娠并发症，如妊娠糖尿病，先兆子痫，胎儿生长异常的确切病因，需要充分阐明。脂肪因子的发现提出了关于它们对这些疾病的分子病理生理学的潜在贡献的问题。多项研究分析了其局部mRNA表达和循环蛋白水平。然而，大多数研究报告了相互矛盾的结果。一些脂肪因子，如瘦素，lipoprotein，irisin，apelin，chemerin和omentin被提出作为异质性妊娠并发症的潜在的新的早期标志物。将脂肪因子纳入标准预测多因素模型可以提高其预后价值。尽管如此，它们的独立诊断价值大多不足以实施到标准临床实践中。在正常妊娠和复杂妊娠的管理中，不建议对妊娠期间脂肪因子水平进行常规评估。基于动物模型（例如，Apelin及其受体在啮齿动物先兆子痫模型中的应用），脂肪因子及其受体作为新的治疗靶点的未来应用似乎是有希望的，但需要在人类中进一步验证。
Adipocytokines are hormonally active molecules that are believed to play a key role in the regulation of crucial biological processes in the human body. Numerous experimental studies established significant alterations in the adipokine secretion patterns throughout pregnancy. The exact etiology of various gestational complications, such as gestational diabetes, preeclampsia, and fetal growth abnormalities, needs to be fully elucidated. The discovery of adipokines raised questions about their potential contribution to the molecular pathophysiology of those diseases. Multiple studies analyzed their local mRNA expression and circulating protein levels. However, most studies report conflicting results. Several adipokines such as leptin, resistin, irisin, apelin, chemerin, and omentin were proposed as potential novel early markers of heterogeneous gestational complications. The inclusion of the adipokines in the standard predictive multifactorial models could improve their prognostic values. Nonetheless, their independent diagnostic value is mostly insufficient to be implemented into standard clinical practice. Routine assessments of adipokine levels during pregnancy are not recommended in the management of both normal and complicated pregnancies. Based on the animal models (e.g., apelin and its receptors in the rodent preeclampsia models), future implementation of adipokines and their receptors as new therapeutic targets appears promising but requires further validation in humans.
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DOI：
10.1530/joe-13-0339
发表时间：
2014-02
期刊：
The Journal of endocrinology
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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发表时间：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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