Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection.
Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection.
复制标题
salvianolic酸：具有多种心血管保护机制的小型化合物。
DOI：
10.1186/1423-0127-18-30
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发表时间：
2011-05-11
影响因子：
11
通讯作者：
Hong CY
中科院分区：
文献类型：
--
作者：
Ho JH;Hong CY
丹酚酸是从丹参中提取的最丰富的水溶性化合物。在中国，丹参被广泛用于治疗心血管疾病已有数百年历史。丹酚酸，尤其是丹酚酸 A (Sal A) 和丹酚酸 B (Sal B)，因其多酚结构而被发现具有有效的抗氧化能力。最近，在各种心血管损伤时，在体外和体内研究了血管内皮细胞、主动脉平滑肌细胞以及心肌细胞中丹酚酸调节的细胞内信号通路。研究发现，丹酚酸对心血管的保护作用不仅是由于丹酚酸作为活性氧清除剂，还与减少白细胞-内皮粘附、抑制主动脉平滑肌细胞炎症和金属蛋白酶表达以及间接调节免疫功能有关。丹酚酸与靶蛋白竞争性结合以中断蛋白质-蛋白质相互作用也被发现是丹酚酸保护心血管的机制。在本文中，我们回顾了针对上述机制的各种研究。此外，还描述了丹酚酸的靶蛋白。这些最新进展的结果为丹酚酸治疗心血管疾病的新治疗策略的开发提供了新的线索。
Salvianolic acids are the most abundant water-soluble compounds extracted from Radix Salvia miltiorrhiza (Danshen). In China, Danshen has been wildly used to treat cardiovascular diseases for hundreds of years. Salvianolic acids, especially salvianolic acid A (Sal A) and salvianolic acid B (Sal B), have been found to have potent anti-oxidative capabilities due to their polyphenolic structure. Recently, intracellular signaling pathways regulated by salvianolic acids in vascular endothelial cells, aortic smooth muscle cells, as well as cardiomyocytes, have been investigated both in vitro and in vivo upon various cardiovascular insults. It is discovered that the cardiovascular protection of salvianolic acids is not only because salvianolic acids act as reactive oxygen species scavengers, but also due to the reduction of leukocyte-endothelial adherence, inhibition of inflammation and metalloproteinases expression from aortic smooth muscle cells, and indirect regulation of immune function. Competitive binding of salvianolic acids to target proteins to interrupt protein-protein interactions has also been found to be a mechanism of cardiovascular protection by salvianolic acids. In this article, we review a variety of studies focusing on the above mentioned mechanisms. Besides, the target proteins of salvianolic acids are also described. These results of recent advances have shed new light to the development of novel therapeutic strategies for salvianolic acids to treat cardiovascular diseases.
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影响因子：
5.8
作者：
LIU, GT;ZHANG, TM;WANG, YW
通讯作者：
WANG, YW
影响因子：
6.4
作者：
Hao, Yubin;Xie, Tianpei;Korotcov, Alexandru;Zhou, Yanfei;Pang, Xiaowu;Shan, Liang;Ji, Hongguang;Sridhar, Rajagopalan;Wang, Paul;Califano, Joseph;Giu, Xinbin
通讯作者：
Giu, Xinbin
影响因子：
13.3
作者：
Wang, Xihong;Morris-Natschke, Susan L.;Lee, Kuo-Hsiung
通讯作者：
Lee, Kuo-Hsiung
影响因子：
4.1
作者：
Chen, YF;Jaw, I;Tsai, TH
通讯作者：
Tsai, TH
影响因子：
1.7
作者：
Hu, P;Liang, QL;Jiang, ZH
通讯作者：
Jiang, ZH