Overexpression of PLIN2 is a prognostic marker and attenuates tumor progression in clear cell renal cell carcinoma.
Overexpression of PLIN2 is a prognostic marker and attenuates tumor progression in clear cell renal cell carcinoma.
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PLIN2 的过度表达是透明细胞肾细胞癌的预后标志物，可减弱肿瘤进展
DOI：
10.3892/ijo.2018.4384
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发表时间：
2018-07
影响因子：
5.2
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Cao Q;Ruan H;Wang K;Song Z;Bao L;Xu T;Xiao H;Wang C;Cheng G;Tong J;Meng X;Liu D;Yang H;Chen K;Zhang X
透明细胞肾细胞癌（ccRCC）是成人中最常见的肾脏恶性肿瘤，其发病率持续增加。脂滴蛋白perilipin 2（PLIN 2）最初被认为是RNA转录物，在脂肪细胞分化期间显著表达。此外，已观察到它在许多类型的癌症中升高，包括ccRCC;然而，其在ccRCC中的基本功能仍不清楚。本研究检查了在ccRCC中PLIN 2的表达，并且旨在确定PLIN 2表达与患者存活之间的关联。本研究通过The Cancer Genome Atlas挖掘了ccRCC患者中PLIN 2的转录、临床病理和生存数据。通过免疫印迹和免疫组化检测PLIN 2在人ccRCC组织和细胞系中的表达水平，并通过功能分析鉴定其生物学作用。结果表明，PLIN 2主要在RCC组织和细胞中升高。此外，PLIN 2的表达水平与各种临床病理因素显著相关，PLIN 2高表达与良好的预后相关。多变量分析的结果表明，PLIN 2高表达是总生存期的独立预后指标（风险比，0.586; P=0.001）。此外，PLIN 2敲低促进ccRCC细胞的增殖，并增强细胞侵袭和迁移。这些结果表明，PLIN 2可能被认为是ccRCC中的一种新的预后因子，也是ccRCC患者的一种特异性诊断指标。此外，它可能是临床治疗ccRCC的潜在新靶点。
Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy in adults, the incidence of which continues to increase. The lipid droplet protein perilipin 2 (PLIN2), which was originally considered an RNA transcript, is markedly expressed during adipocyte differentiation. In addition, it has been observed to be elevated in numerous types of cancer, including ccRCC; however, its essential function remains unclear in ccRCC. The present study examined the expression of PLIN2 in ccRCC, and aimed to determine the association between PLIN2 expression and patient survival. The present study mined the transcriptional, clinicopathological and survival data of PLIN2 in patients with ccRCC through The Cancer Genome Atlas. The expression levels of PLIN2 were also detected in human ccRCC tissues and cell lines by western blotting and immunohistochemistry, and its biological role was identified by functional analysis. The results demonstrated that PLIN2 was predominantly elevated in RCC tissues and cells. In addition, the expression levels of PLIN2 were significantly associated with various clinicopathological factors, and high PLIN2 expression was associated with a good prognosis. The results of a multivariate analysis demonstrated that high PLIN2 expression was an independent prognostic indicator of overall survival (hazard ratio, 0.586; P=0.001). Furthermore, PLIN2 knockdown promoted proliferation of ccRCC cells, and enhanced cell invasion and migration. These results suggested that PLIN2 may be considered a novel prognostic factor in ccRCC and a specific diagnostic indicator for patients with ccRCC. Furthermore, it could be a potential novel target for the clinical treatment of ccRCC.
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影响因子：
23.4
作者：
Moch, Holger;Cubilla, Antonio L.;Ulbright, Thomas M.
通讯作者：
Ulbright, Thomas M.
影响因子：
6.5
作者：
Kimmel AR;Brasaemle DL;McAndrews-Hill M;Sztalryd C;Londos C
通讯作者：
Londos C
影响因子：
2.5
作者：
Lu, XY;Gruia-Gray, J;Kimmel, AR
通讯作者：
Kimmel, AR
影响因子：
1.7
作者：
Fujimoto, Masakazu;Matsuzaki, Ibu;Murata, Shin-ichi
通讯作者：
Murata, Shin-ichi
DOI：
10.1038/oby.2005.160
发表时间：
2005-08-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Phillips, SA;Choe, CC;Henry, RR
通讯作者：
Henry, RR