Deep phenotyping of the unselected COPSAC2010 birth cohort study.
Deep phenotyping of the unselected COPSAC2010 birth cohort study.
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DOI：
10.1111/cea.12213
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Bønnelykke K
中科院分区：
文献类型：
--
作者：
Bisgaard H;Vissing NH;Carson CG;Bischoff AL;Følsgaard NV;Kreiner-Møller E;Chawes BL;Stokholm J;Pedersen L;Bjarnadóttir E;Thysen AH;Nilsson E;Mortensen LJ;Olsen SF;Schjørring S;Krogfelt KA;Lauritzen L;Brix S;Bønnelykke K
我们假设围产期暴露，特别是怀孕期间的人类微生物组和母体营养，与遗传易感性相互作用，导致生命早期异常的免疫调节，从而导致慢性炎症性疾病，如哮喘和其他疾病。本研究的目的是通过对未选择的孕妇及其后代进行纵向研究来探索这些相互作用，重点是深入临床表型，暴露评估和生物银行。暴露评估侧重于人类微生物组。在随机对照试验中，怀孕期间的营养干预被纳入研究，以预防疾病并能够建立因果关系。2008-2010年期间，来自丹麦东部的孕妇被邀请参加一个新颖的未选定的“COPSAC2010”队列。这些妇女在怀孕第24周和第36周期间访问了该诊所。他们的孩子在诊所进行了深入的表型分析，并在9次定期访问中收集生物样本，直到3岁和急性症状。在怀孕期间进行了高剂量维生素D和鱼油补充剂的随机对照试验，并在复发性喘息儿童中进行了阿奇霉素治疗急性肺部症状的试验。从妊娠第24周开始招募了738名母亲，其中700名孩子被纳入出生队列。该队列中特异反应性父母的比例过高。参与者满意度高，依从性同样高，参加1年门诊就诊的儿童有685名（98%），参加2年门诊就诊的儿童有667名（95%）。COPSAC2010出生队列研究提供了纵向临床随访，具有高度特异性的终点，暴露评估和生物库。该队列具有较高的依从率，有望提供强有力的数据来阐明基因组学与围产期暴露体之间的相互作用，从而导致与生活方式相关的慢性炎症性疾病，如哮喘。
We hypothesize that perinatal exposures, in particular the human microbiome and maternal nutrition during pregnancy, interact with the genetic predisposition to cause an abnormal immune modulation in early life towards a trajectory to chronic inflammatory diseases such as asthma and others. The aim of this study is to explore these interactions by conducting a longitudinal study in an unselected cohort of pregnant women and their offspring with emphasis on deep clinical phenotyping, exposure assessment, and biobanking. Exposure assessments focus on the human microbiome. Nutritional intervention during pregnancy in randomized controlled trials are included in the study to prevent disease and to be able to establish causal relationships. Pregnant women from eastern Denmark were invited during 2008–2010 to a novel unselected ‘COPSAC2010’ cohort. The women visited the clinic during pregnancy weeks 24 and 36. Their children were followed at the clinic with deep phenotyping and collection of biological samples at nine regular visits until the age of 3 and at acute symptoms. Randomized controlled trials of high‐dose vitamin D and fish oil supplements were conducted during pregnancy, and a trial of azithromycin for acute lung symptoms was conducted in the children with recurrent wheeze. Seven hundred and thirty‐eight mothers were recruited from week 24 of gestation, and 700 of their children were included in the birth cohort. The cohort has an over‐representation of atopic parents. The participant satisfaction was high and the adherence equally high with 685 children (98%) attending the 1 year clinic visit and 667 children (95%) attending the 2 year clinic visit. The COPSAC2010 birth cohort study provides longitudinal clinical follow‐up with highly specific end‐points, exposure assessments, and biobanking. The cohort has a high adherence rate promising strong data to elucidate the interaction between genomics and the exposome in perinatal life leading to lifestyle‐related chronic inflammatory disorders such as asthma.
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影响因子：
158.5
作者：
Bisgaard, Hans;Hermansen, Mette Northman;Pipper, Christian Bressen
通讯作者：
Pipper, Christian Bressen
影响因子：
5.9
作者：
Bisgaard, H
通讯作者：
Bisgaard, H
影响因子：
5.2
作者：
Gammelgaard, A.;Knudsen, L. E.;Bisgaard, H.
通讯作者：
Bisgaard, H.
影响因子：
3.1
作者：
Bisgaard, Hans;Szefler, Stanley
通讯作者：
Szefler, Stanley
DOI：
10.1164/rccm.201108-1471oc
发表时间：
2012-02-01
影响因子：
24.7
作者：
Folsgaard, Nilofar V.;Chawes, Bo L.;Bisgaard, Hans
通讯作者：
Bisgaard, Hans