Polycaprolactone (PCL)-Polylactic Acid (PLA)-Glycerol (Gly) Composites Incorporated with Zinc Oxide Nanoparticles (ZnO-NPs) and Tea Tree Essential Oil (TTEO) for Tissue Engineering Applications.
Polycaprolactone (PCL)-Polylactic Acid (PLA)-Glycerol (Gly) Composites Incorporated with Zinc Oxide Nanoparticles (ZnO-NPs) and Tea Tree Essential Oil (TTEO) for Tissue Engineering Applications.
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DOI：
10.3390/pharmaceutics15010043
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发表时间：
2022-12-22
期刊：
影响因子：
5.4
通讯作者：
Chaur, Manuel N.
中科院分区：
文献类型：
--
作者：
Grande-Tovar, Carlos David;Castro, Jorge Ivan;Valencia Llano, Carlos Humberto;Tenorio, Diego Lopez;Saavedra, Marcela;Zapata, Paula A.;Chaur, Manuel N.
由于各种组织中的事故和疾病（如癌症）的巨大需求，在生物医学应用中寻找可替代侵入性材料的新生物相容性材料的研究有所增加。在这个意义上说，四个配方的基础上聚己内酯（PCL）和聚乳酸（PLA）与氧化锌纳米粒子（ZnO-NPs）和茶树精油（TTEO）。采用溶胶-凝胶法制备了平均粒径为11 ± 2 nm的球形氧化锌纳米粒子。另一方面，傅里叶变换红外光谱（FTIR）显示了每个复合材料组分的特征官能团。制剂中的TTEO掺入与C-O-C带的强度增加有关。材料的热性能表明，ZnO纳米粒子的降解性能降低了热稳定性。通过扫描电子显微镜（SEM）的形态学研究表明，TTEO和ZnO-NPs的存在协同作用，获得光滑的表面，而具有ZnO-NPs或TTEO的存在的膜仅显示多孔形态。植入60天后，膜的组织学植入显示生物相容性和生物降解性。这种降解通过较大颗粒的破碎发生，存在由III型胶原纤维、血管和炎性细胞构成的结缔组织，其中植入材料的再吸收过程继续。
The search for new biocompatible materials that can replace invasive materials in biomedical applications has increased due to the great demand derived from accidents and diseases such as cancer in various tissues. In this sense, four formulations based on polycaprolactone (PCL) and polylactic acid (PLA) incorporated with zinc oxide nanoparticles (ZnO-NPs) and tea tree essential oil (TTEO) were prepared. The sol-gel method was used for zinc oxide nanoparticle synthesis with an average size of 11 ± 2 nm and spherical morphology. On the other hand, Fourier Transformed infrared spectroscopy (FTIR) showed characteristic functional groups for each composite component. The TTEO incorporation in the formulations was related to the increased intensity of the C-O-C band. The thermal properties of the materials show that the degradative properties of the ZnO-NPs decrease the thermal stability. The morphological study by scanning electron microscopy (SEM) showed that the presence of TTEO and ZnO-NPs act synergistically, obtaining smooth surfaces, whereas membranes with the presence of ZnO-NPs or TTEO only show porous morphologies. Histological implantation of the membranes showed biocompatibility and biodegradability after 60 days of implantation. This degradation occurs through the fragmentation of the larger particles with the presence of connective tissue constituted by type III collagen fibers, blood vessels, and inflammatory cells, where the process of resorption of the implanted material continues.
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用于生物医学应用的壳聚糖/聚乙烯醇/茶树精油复合膜。
影响因子：
5
作者：
Castro JI;Valencia-Llano CH;Valencia Zapata ME;Restrepo YJ;Mina Hernandez JH;Navia-Porras DP;Valencia Y;Valencia C;Grande-Tovar CD
通讯作者：
Grande-Tovar CD
影响因子：
3.6
作者：
Jordan, Sumanas W.;Fligor, Jennifer E.;Dumanian, Gregory A.
通讯作者：
Dumanian, Gregory A.
DOI：
10.1590/1678-775720160044
发表时间：
2016-11
期刊：
Journal of applied oral science : revista FOB
影响因子：
--
作者：
Graziano TS;Calil CM;Sartoratto A;Franco GC;Groppo FC;Cogo-Müller K
通讯作者：
Cogo-Müller K
影响因子：
3.2
作者：
Correia, Carlos;Gomes, Tiago E. P.;Neto, Victor
通讯作者：
Neto, Victor
影响因子：
8.4
作者：
Ahtzaz, Samreen;Nasir, Muhammad;Rehman, Ihtesham Ur
通讯作者：
Rehman, Ihtesham Ur