Evolution of trappin genes in mammals.
Evolution of trappin genes in mammals.
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DOI：
10.1186/1471-2148-10-31
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发表时间：
2010-01-29
影响因子：
3.4
通讯作者：
Hirose S
中科院分区：
文献类型：
--
作者：
Kato A;Rooney AP;Furutani Y;Hirose S
Trappin是一种多功能的宿主防御肽，具有抗蛋白分解、抗炎和抗微生物活性。在不同的哺乳动物物种中，trappin parals的数量和组成有所不同：人和羊只有一个trappin-2基因；小鼠和大鼠没有trappin基因；猪和牛有多个trappin基因；豚鼠有trappin基因和另外两个衍生基因。最近在猪和牛的物种分离后观察到了Trappin基因的独立复制。为了确定这些Trappin基因复制是否仅限于某些哺乳动物谱系，我们分析了最近开发的基因组数据库中存在重复Trappin基因的情况。对数据库的分析表明：1)最近在九带螳螂中发现了重复的trappin多基因；2)自古以来在非动物物种(大象、Tenrec和Hyrax)中发现了两个重复的trappin基因；3)在各种真兽类物种中发现了单一的trappin-2基因；4)在鸡、斑马雀和负鼠中没有发现典型的trappin基因。贝叶斯分析估计，非泡沫动物、豚鼠、螳螂、奶牛和猪中Trappin基因的复制日期分别为244年、35年、11年、13年和300万年前。杏仁、牛和猪的Trappin多基因编码区的进化速度远远快于非编码外显子、内含子和侧翼区，表明这些基因经历了加速进化，并且在猪特有的Trappin Paralog中观察到了正的达尔文选择。这些结果表明，Trappin是真兽类特有的分子，真兽类基因组有可能形成Trappin多基因。
Trappin is a multifunctional host-defense peptide that has antiproteolytic, antiinflammatory, and antimicrobial activities. The numbers and compositions of trappin paralogs vary among mammalian species: human and sheep have a single trappin-2 gene; mouse and rat have no trappin gene; pig and cow have multiple trappin genes; and guinea pig has a trappin gene and two other derivativegenes. Independent duplications of trappin genes in pig and cow were observed recently after the species were separated. To determine whether these trappin gene duplications are restricted only to certain mammalian lineages, we analyzed recently-developed genome databases for the presence of duplicate trappin genes. The database analyses revealed that: 1) duplicated trappin multigenes were found recently in the nine-banded armadillo; 2) duplicated two trappin genes had been found in the Afrotherian species (elephant, tenrec, and hyrax) since ancient days; 3) a single trappin-2 gene was found in various eutherians species; and 4) no typical trappin gene has been found in chicken, zebra finch, and opossum. Bayesian analysis estimated the date of the duplication of trappin genes in the Afrotheria, guinea pig, armadillo, cow, and pig to be 244, 35, 11, 13, and 3 million-years ago, respectively. The coding regions of trappin multigenes of almadillo, bovine, and pig evolved much faster than the noncoding exons, introns, and the flanking regions, showing that these genes have undergone accelerated evolution, and positive Darwinian selection was observed in pig-specific trappin paralogs. These results suggest that trappin is an eutherian-specific molecule and eutherian genomes have the potential to form trappin multigenes.
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影响因子：
2.7
作者：
Furutani, Y;Kato, A;Hirose, S
通讯作者：
Hirose, S
影响因子：
4.8
作者：
Furutani, Y;Kato, A;Hirose, S
通讯作者：
Hirose, S
影响因子：
2.7
作者：
NARA, K;ITO, S;HIROSE, S
通讯作者：
HIROSE, S
Ensembl 2009。
影响因子：
14.9
作者：
Hubbard TJ;Aken BL;Ayling S;Ballester B;Beal K;Bragin E;Brent S;Chen Y;Clapham P;Clarke L;Coates G;Fairley S;Fitzgerald S;Fernandez-Banet J;Gordon L;Graf S;Haider S;Hammond M;Holland R;Howe K;Jenkinson A;Johnson N;Kahari A;Keefe D;Keenan S;Kinsella R;Kokocinski F;Kulesha E;Lawson D;Longden I;Megy K;Meidl P;Overduin B;Parker A;Pritchard B;Rios D;Schuster M;Slater G;Smedley D;Spooner W;Spudich G;Trevanion S;Vilella A;Vogel J;White S;Wilder S;Zadissa A;Birney E;Cunningham F;Curwen V;Durbin R;Fernandez-Suarez XM;Herrero J;Kasprzyk A;Proctor G;Smith J;Searle S;Flicek P
通讯作者：
Flicek P
DOI：
10.1006/bbrc.1996.0594
发表时间：
1996-04-16
影响因子：
3.1
作者：
Lundwall, A;Ulvsback, M
通讯作者：
Ulvsback, M