Age-related changes in insula cortical thickness and impulsivity: significance for emotional development and decision-making.
Age-related changes in insula cortical thickness and impulsivity: significance for emotional development and decision-making.
复制标题
DOI：
10.1016/j.dcn.2013.07.001
复制
发表时间：
2013-10
影响因子：
4.7
通讯作者：
Yurgelun-Todd DA
中科院分区：
文献类型：
--
作者：
Churchwell JC;Yurgelun-Todd DA
岛叶皮层的隔室显示出与年龄相关的减少。与年龄相关的未来取向和计划也会增加。年龄在10-22岁的参与者被评估冲动和核磁共振成像。我们报告了年龄与非规划/前岛厚度成反比关系。我们还观察到脑岛厚度与非计划性呈正相关。脑岛功能与情绪调节有关，在风险、回报和损失预期、对未来奖励的折扣和自评冲动下调整结果。脑岛在这些过程中的作用可能从根本上与前瞻性思维有关，这种特征随着年龄的增长而增加。有证据表明，岛叶皮质厚度显示出与年龄相关的未来取向和计划的减少，而与年龄相关的未来取向和计划的增加。我们检验了非计划性随年龄增长而减少的假设，以及脑岛厚度与年龄和非计划性冲动都有关的假设。59名年龄从10岁到22岁的男性和女性参与者接受了结构磁共振成像（MRI）检查，并使用Barratt冲动量表（BIS）进行了评估。我们发现，脑岛前部厚度和非计划性冲动与年龄呈负相关，而脑岛前部厚度与非计划性冲动呈显著的线性正相关。
Compartments of insular cortex show age-related decreases. Age-related increases in future orientation and planning also occur. Participants aged 10–22 years were assessed for impulsivity and with MRI. We report an inverse relationship for age and nonplanning/anterior insula thickness. We also observed a positive relationship between insula thickness and nonplanning. Insula function has been associated with emotional regulation, adjusting to changing outcomes under risk, reward and loss anticipation, discounting of future rewards, and self-rated impulsivity. The role of the insula in these processes may be fundamentally related to prospective thinking, a trait that increases with age. There is evidence that insular cortical thickness shows age related decreases that parallel age related increases in future orientation and planning. We tested the hypothesis that nonplanning decreases with age and that insula thickness is related to both age and nonplanning impulsivity. Fifty-nine male and female participants, ranging in age from 10 to 22 years old, underwent structural magnetic resonance imaging (MRI) procedures and were assessed using the Barratt Impulsiveness Scale (BIS). We observed that anterior insula thickness and nonplanning impulsivity show an inverse relationship with age and that there is a significant positive linear relationship between anterior insula thickness and nonplanning.
登录
查看更多内容
DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
2.5
作者：
Lee, Tatia M. C.;Chan, Chetwyn C. H.;Gao, Jia-Hong
通讯作者：
Gao, Jia-Hong
影响因子：
3.6
作者：
Geier, Charles;Luna, Beatriz
通讯作者：
Luna, Beatriz
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
8.2
作者：
Brenhouse, Heather C.;Andersen, Susan L.
通讯作者：
Andersen, Susan L.