Synaptic interactions underlying song-selectivity in the avian nucleus HVC revealed by dual intracellular recordings.
Synaptic interactions underlying song-selectivity in the avian nucleus HVC revealed by dual intracellular recordings.
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双重细胞内记录揭示了鸟类核 HVC 中歌曲选择性的突触相互作用。
DOI：
10.1152/jn.00100.2005
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发表时间：
2006
影响因子：
2.5
通讯作者：
Mooney,Richard
中科院分区：
文献类型：
--
作者：
Rosen,MerriJ;Mooney,Richard
在专门用于感觉处理和感觉运动整合的神经回路中，选择性感觉表征的刺激依赖性突触相互作用仍然知之甚少。鸣禽端脑核HVC是一个感觉运动区必不可少的学习声乐控制与一个投射神经元（PN）型（HVCRA）支配的歌曲运动前通路，另一个PN（HVCX）支配的基底神经节途径必不可少的声乐可塑性，和中间神经元（HVCInt）。播放鸟自己的歌（BOS），而不是其他歌曲，唤起动作电位爆发从两个PN，但HVCRA和HVCX显示不同的BOS诱发的阈下反应。为了表征HVC的BOS选择性反应的突触相互作用，并评估HVC神经元之间的功能相互作用的刺激诱发的变化，我们同时在体内的细胞内记录从各种HVC神经元对在麻醉斑马雀。尖峰触发的平均显示，所有的HVC神经元类型接收共同的兴奋，这种兴奋的发作发生在一个较窄的时间窗口在投射神经元在BOS播放。为了区分HVC阈下反应模式的局部和外部贡献，我们在单个HVCX细胞中用GABA或闭塞抑制来灭活HVC局部回路。两种处理后，BOS诱发的HVCX神经元反应变为纯粹的去极化，HVCX和HVCRA细胞的阈下反应变得非常相似，同时保持BOS选择性。因此，这两种PN类型接收一个共同的外部源的BOS选择性兴奋，和局部抑制，特别是改变处理的听觉信息在HVCX细胞。在HVC中，兴奋性和抑制性突触相互作用以刺激依赖的方式被招募，影响BOS局部和其他对歌曲学习和产生重要的歌曲核团的听觉表征。
Stimulus-dependent synaptic interactions underlying selective sensory representations in neural circuits specialized for sensory processing and sensorimotor integration remain poorly understood. The songbird telencephalic nucleus HVC is a sensorimotor area essential to learned vocal control with one projection neuron (PN) type (HVCRA) innervating a song premotor pathway, another PN (HVCX) innervating a basal ganglia pathway essential to vocal plasticity, and interneurons (HVCInt). Playback of the bird's own song (BOS), but not other songs, evokes action potential bursts from both PNs, but HVCRAand HVCXdisplay distinct BOS-evoked subthreshold responses. To characterize synaptic interactions underlying HVC's BOS-selective responses and assess stimulus-evoked changes in functional interactions between HVC neurons, we made simultaneous in vivo intracellular recordings from various HVC neuron pairs in urethan-anesthetized zebra finches. Spike-triggered averaging revealed that all HVC neuron types receive common excitation and that the onset of this excitation occurs during a narrower time window in projection neurons during BOS playback. To distinguish local from extrinsic contributions to HVC subthreshold response patterns, we inactivated the HVC local circuit with GABA or occluded inhibition in single HVCXcells. After either treatment, BOS-evoked responses in HVCXneurons became purely depolarizing and subthreshold responses of HVCXand HVCRAcells became remarkably similar to one another while retaining BOS selectivity. Therefore both PN types receive a common extrinsic source of BOS-selective excitation, and local inhibition specifically alters processing of auditory information in HVCXcells. In HVC, excitatory and inhibitory synaptic interactions are recruited in a stimulus-dependent fashion, affecting auditory representations of the BOS locally and in other song nuclei important to song learning and production.
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