Tick Saliva and Salivary Glands: What Do We Know So Far on Their Role in Arthropod Blood Feeding and Pathogen Transmission.
Tick Saliva and Salivary Glands: What Do We Know So Far on Their Role in Arthropod Blood Feeding and Pathogen Transmission.
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DOI：
10.3389/fcimb.2021.816547
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发表时间：
2021
影响因子：
5.7
通讯作者：
Sultana H
中科院分区：
文献类型：
--
作者：
Neelakanta G;Sultana H
蜱虫是一种吸血节肢动物，它们进化出了无数种从脊椎动物宿主那里吸血的策略。它们首先附着在宿主的皮肤上，选择一个咬的地方吸血，在咬的地方创造一个进食的生态位，在唾液中分泌大量的分子，然后开始进食。另一方面，宿主防御会试图反击并阻止蜱虫在叮咬部位进食。在蜱虫和寄主之间的持续战斗中，节肢动物成功地安抚了寄主，并完成了一顿血餐，然后在充分充血后补充。在这篇综述中，我们讨论了一些已知的和新兴的节肢动物成分，如水泥、唾液蛋白、脂钙蛋白、热休克蛋白70、oops和细胞外囊泡/外泌体在促进蜱成功采血中的作用。此外，我们还讨论了蜱传病原体如何调节这些成分来感染脊椎动物宿主。了解节肢动物取血的生物学和病原体传播过程中蜱-宿主界面的分子相互作用是非常重要的。这些信息最终将引导我们确定开发传播阻断疫苗的候选疫苗，以预防医学上重要的媒介传播病原体引起的疾病。
Ticks are blood-sucking arthropods that have developed myriad of strategies to get a blood meal from the vertebrate host. They first attach to the host skin, select a bite site for a blood meal, create a feeding niche at the bite site, secrete plethora of molecules in its saliva and then starts feeding. On the other side, host defenses will try to counter-attack and stop tick feeding at the bite site. In this constant battle between ticks and the host, arthropods successfully pacify the host and completes a blood meal and then replete after full engorgement. In this review, we discuss some of the known and emerging roles for arthropod components such as cement, salivary proteins, lipocalins, HSP70s, OATPs, and extracellular vesicles/exosomes in facilitating successful blood feeding from ticks. In addition, we discuss how tick-borne pathogens modulate(s) these components to infect the vertebrate host. Understanding the biology of arthropod blood feeding and molecular interactions at the tick-host interface during pathogen transmission is very important. This information would eventually lead us in the identification of candidates for the development of transmission-blocking vaccines to prevent diseases caused by medically important vector-borne pathogens.
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影响因子：
3.4
作者：
Dai SX;Zhang AD;Huang JF
通讯作者：
Huang JF
影响因子：
7.3
作者：
Ahmed W;Neelakanta G;Sultana H
通讯作者：
Sultana H
影响因子：
2.6
作者：
de la Fuente, Jose;Moreno-Cid, Juan A.;Blouin, Edmour F.
通讯作者：
Blouin, Edmour F.
影响因子：
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作者：
Anguita, J;Ramamoorthi, N;Fikrig, E
通讯作者：
Fikrig, E
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4
作者：
BINNINGTON, KC;STONE, BF
通讯作者：
STONE, BF